TY  - JOUR
T1  - Reversible Nephrotoxicity of Colistin
TT  - Geri Dönüşümlü Kolistin Nefrotoksisitesi
AU  - Çınar, Güle
PY  - 2019
DA  - June
DO  - 10.4274/atfm.galenos.2019.75047
JF  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
PB  - Ankara University
WT  - DergiPark
SN  - 0365-8104
SP  - 111
EP  - 113
VL  - 72
IS  - 1
LA  - en
AB  - Both nosocomial and community acquired gram-negative bacterial infections cause serious morbidity and mortality. However, old antibiotics, whichhave toxic side effects, should be re-used because of the lack of newly developed antibiotics. One of these is colistin which has both nephrotoxicand neurotoxic side effects. Especially due to nephrotoxicity side effec, serious problems can be experienced in the use of colistin. In this article, acase of reversible nephrotoxicity after colistin usage is presented.
KW  - Colistin
KW  - Nephrotoxicity
KW  - Reversible
N2  - Hem toplum kökenli hem de hastane kökenli gram negatif bakteri enfeksiyonları ciddi morbidite ve mortalite nedenidir. Ancak yeni geliştirilenantibiyotikler pek olmadığı için toksik yan etkileri bulunan eski antibiyotikler tekrar kullanılmak durumundadır. Bunlardan bir tanesi de hem nefrotoksikhem nörotoksik yan etkisi bulunan kolistindir. Özellikle nefrotoksisite yan etkisi nedeniyle kolistin kullanımında ciddi sıkıntılar yaşanabilmektedir. Bumakalede, kolistin kullanımı sonrasında geri dönüşümlü nefrotoksisite gelişen bir olgu sunulmuştur
CR  - 1. WHO. Global priority lidt of antibiotic-resistant bacteria guide research, discovery and development of new antibiotics. http://wwwwhoint/ medicines/publications/global-priority-list-antibiotic-resistant-bacteria/ en/.2016.
CR  - 2. Yahav D, Farbman L, Leibovici L, et al. Colistin: new lessons on an old antibiotic. Clin Microbiol Infect. 2012;18:18-29.
CR  - 3. Munoz-Price LS, Poirel L, Bonomo RA, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13:785-796.
CR  - 4. Dalfino L, Puntillo F, Ondok MJ, et al. Colistin-associated Acute Kidney Injury in Severely Ill Patients: A Step Toward a Better Renal Care? A Prospective Cohort Study. Clin Infect Dis. 2015;61:1771-1777.
CR  - 5. Vaara M. Polymyxins and their novel derivatives. Curr Opin Microbiol. 2010;13:574-581.
CR  - 6. Mendes CA, Burdman EA. [Polymyxins - review with emphasis on nephrotoxicity]. Rev Assoc Med Bras (1992). 2009;55:752-759.
CR  - 7. Falagas ME, Kasiakou SK. Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. Crit Care. 2006;10:R27.
CR  - 8. Mert A. Kolistin toksisitesi, ANKEM Derg. 2012; 26(Ek 2):22-26.
CR  - 9. Temocin F, Erdinc S, Tulek N, et al. Incidence and Risk Factors for Colistin- Associated Nephrotoxicity. Jpn J Infect Dis. 2015;68:318-320.
CR  - 10. Köksal İ, Kaya S, Gençalioğlu E, Yılmaz G. İntravenöz kolistin kullanımıyla ilişkili olarak gelişen nefrotoksisite, 6.Tepecik Enfeksiyon Günleri, Poster no.17, Muğla (2015).
CR  - 11. Wang J, Niu H, Wang R, et al. Safety and efficacy of colistin alone or in combination in adults with Acinetobacter baumannii infection: A systematic review and meta analysis. Int J Antimicrob Agents. 2018 Nov 14. pii: S0924-8579:30312-1.
UR  - https://doi.org/10.4274/atfm.galenos.2019.75047
L1  - https://dergipark.org.tr/en/download/article-file/4936842
ER  -