TY  - JOUR
T1  - Severe serotonin syndrome due to high-dose venlafaxine: A rare case successfully managed with chlorpromazine
TT  - Yüksek doz venlafaksine bağlı şiddetli serotonin sendromu: Klorpromazin ile başarıyla yönetilen nadir bir olgu
AU  - Kiziltunc, Husnu Serdar
AU  - Duman, Mehmet Batuhan
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.61845/agrimedical.1716160
JF  - Ağrı Tıp Fakültesi Dergisi
JO  - Ağrı Med J
PB  - Ağrı İbrahim Çeçen University
WT  - DergiPark
SN  - 2980-0978
SP  - 134
EP  - 138
VL  - 3
IS  - 3
LA  - en
AB  - Serotonin syndrome is a potentially life-threatening clinical condition caused by excessive serotonergic activity within the central nervous system. In this report, we present the case of a 40-year-old woman with a diagnosis of major depressive disorder who developed serotonin syndrome following a suicidal ingestion of 3000 mg extended-release venlafaxine. The patient manifested agitation, clonus, generalized tonic–clonic seizures, and altered mental status. Despite intensive supportive care and administration of oral cyproheptadine, no clinical improvement was achieved. However, following intramuscular administration of 25 mg chlorpromazine, the patient demonstrated rapid neurological and hemodynamic recovery. This case highlights that severe serotonin syndrome may occur after ingestion of a single serotonergic agent at high doses, and that chlorpromazine may provide therapeutic benefit in cases where conventional treatments fail.
KW  - Serotonin syndrome
KW  - Venlafaxine hydrochloride
KW  - Chlorpromazine
N2  - Serotonin sendromu, merkezi sinir sistemindeki aşırı serotonerjik aktiviteye bağlı olarak gelişen, potansiyel olarak yaşamı tehdit edebilen klinik bir tablodur. Bu yazıda, majör depresif bozukluk tanısıyla takip edilen ve suisidal amaçlı 3000 mg uzatılmış salınımlı venlafaksin alan 40 yaş kadın hastada gelişen serotonin sendromu olgusu sunulmaktadır. Hastada ajitasyon, klonus, jeneralize tonik-klonik nöbet ve bilinç değişikliği gelişmiştir. Yoğun destek tedavisi ve oral siproheptadin uygulanmasına rağmen klinik düzelme sağlanamamıştır. Ancak intramüsküler yoldan 25 mg klorpromazin uygulanmasının ardından hastada hızlı nörolojik ve hemodinamik iyileşme gözlenmiştir. Bu olgu, tek bir serotonerjik ajanın yüksek doz alımı sonrasında ciddi serotonin sendromu gelişebileceğini ve konvansiyonel tedavilerin yetersiz kaldığı durumlarda klorpromazinin terapötik fayda sağlayabileceğini desteklemektedir.
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UR  - https://doi.org/10.61845/agrimedical.1716160
L1  - https://dergipark.org.tr/en/download/article-file/4943860
ER  -