@article{article_1720555, title={Neuroprotective Effect of Paeonol in the Rat Model of Traumatic Brain Injury}, journal={Ankara Üniversitesi Tıp Fakültesi Mecmuası}, volume={73}, pages={42–46}, year={2020}, DOI={10.4274/atfm.galenos.2020.35229}, author={Arık, Emine and Dolgun, Habibullah and Kuru Bektaşoğlu, Pınar and Ergil, Julide and Coşkun, Banu and Tönge, Çağhan and Öztürk, Özden Çağlar and Gürses, Levent and Gürer, Bora}, keywords={Anti-edema, Neuroprotection, Paeonol, Traumatic Brain Injury}, abstract={Objectives: Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage. Several animal models have shown paeonol to be a powerful antioxidant, antiapoptotic, and neuroprotective substance. This study aimed to investigate possible neuroprotective effects of paeonol in a rat TBI model. Materials and Methods: Thirty-two male rats were divided into four groups: control, trauma, vehicle, and paeonol groups. Trauma, vehicle, and paeonol groups were subjected to closed-head, contusive weight-drop injuries. The vehicle (saline) or paeonol (50 mg/kg) was orally administered as premedication for 15 days. Brain samples were obtained 24 hours after trauma. Histomorphological evaluation of the cerebral cortex was performed using electron and light microscopy. Results: Histopathological examination revealed that the TBI-induced cerebral cortex damage was less in the paeonol group. Conclusion: Paeonol exhibited neuroprotective and anti-edematous effects against TBI.}, number={1}, publisher={Ankara University}