@article{article_1720634, title={Kronik Spontan Ürtikerde Siklosporin Tedavisi İle İlgili Gözlemlerimiz}, journal={Ankara Üniversitesi Tıp Fakültesi Mecmuası}, volume={69}, pages={107–110}, year={2016}, author={Karakök, Hilayda and Saral, Seçil and Maden, Ayșenur and Kundakçı, Nihal and Doğanay Erdoğan, Beyza and Akay, Bengü Nisa}, keywords={Chronic Urticaria, Cyclosporine, urticaria}, abstract={Aim: Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigateefficacy and safety of cyclosporine in patients with chronic urticaria.
Material and Method: Twenty patients with chronic spontaneous urticaria whom detailed physical examinationwere noted and were treated in our center between 2005 and 2013 were included in this study Results: A total 20 patients were included in this study. Daily wheal number and number of angioedema attackshad been compared and significant reduce in both parameters were detected. Total duration of treatmentwas mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were(min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two patientsunder treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 patient. We observed elevated creatinine levels in 3 patients. Conclusion: A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticariafor a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy.}, number={2}, publisher={Ankara University}