TY - JOUR T1 - Atrial Natüretik Polipeptidlerin Kalp Ve Başka Organ Hücrelerindeki Dağılımının İmmunhisto Kimyasal Değerlendirilmesi TT - ATRİAL NATÜRETİK POLİPEPTİDLERİN KALP ve BAŞKA ORGAN HÜCRELERİNDEKİ DAĞILİMİNİN İMMÜNHİSTO KİMYASAL DEĞERLENDİRİLMESİ AU - Saraç, F. Nurşen PY - 1990 DA - September JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 803 EP - 808 VL - 43 IS - 3 LA - tr AB - Memelilerin atrium kas hücrelerinde çoğunlukla yuvarlak, elek- iron yoğun granüller bulunmaktadır, Bu granüller natriuretik ve vazoğilatator etkili bir çeşit peptidleri içerirler ve immunohistokimyasal yöntemlerle boyanırlar. Bu immunreaktif atrial natriüretik polipeptidler C(ANP) aynı zamanda pulmoner venlerde, veya kavalarda ,tük- rük bezlerinde, böbreklerde, adrenal bez meduilasunda hipofiz bezinde ve beyinde de gözlenmiştir, KW - atrial natriüretik polypep- toddler (AMP) KW - atrium kas hücreleri KW - granüller N2 - Large population of spherical, electron-opague granules are characteristically found in muscle fibers of mammalian atria. These granules have a variety of peptides with natriuretic and vasorelaxant activities, which can be stained by immunohistochemical methods. These immunoreactive atrial natriuretic factors (ANF) were also detected in ventricules, pulmonary vein, venae cavae, salivary glands, kidneys, adrenal medulla, pituitary glands and brain. CR - 1.Bompiani GD Rouiller C and Hetl : Le tissue de conduction du coeur chez le rat Etude au microscope electroniguşe Arch mal Coeur 52 : 1257-1274, 1959. CR - 2.Bloom and Fawcet DW ; A text book of Histology 1986 W.B. Saunders Company Phiadelphia Sayfa : 265. CR - 3.Cantin M Timm-Kennedy M El-Khatib E Huet M : Ultra structural cytochemistry of atriah muscle cells Anat. Rec. 193 : 55-70, 1979. CR - 4.Cantin M Gut kowska J Thibault G Milne AW : Immunocytochemisal loca lization of gtrial natriuretic factor in the heart and salivary glands. Histochemistry 80 ; 113-127, 1984. CR - 5.Garcia AR Cantin M Thibault M : Relation ship of specifiç granules to the natriuretic and diuretic aktivity of rat atria. Experienta 38 : 1071-1073, 1982. CR - 6.Jacobowitz DM Scofitseh G : Evidence for the existence of atrial natriuretic factor containing neurons in the rat brain. Neuroendocrinology 40 ; 92-94, 1985.8. CR - 7.Jamieson JD Palade GE ; Specific granules in atrial muscl-cells. J. Cell Biol 23 : 151-172, 1984. CR - 8.Kangawa K Fukuda A Matsuo H : Structural Identification of 8-and y-human atrial natriuretic polypeptides. Nature 313 : 397-400, 1985. CR - 9.Kawata M Ueda S Nakao K : Immuno-histo chemical demonstration of «-atrial natriuretic poly peptide-containing neurons in the rat brain : Histochemisiry CR - 83 : 1-3, 1985. CR - 10..Kisch B ; Electron microscopy of the atrium of the heart 1. Guinea pig. Exp. Med, Surg. 14 : 99-112, 1956. CR - 11.Mc Kenzie JC Tanaka, J Kunios S : Immuno cytochemical Jokalization of atrial natriuretic factor in the kidney, adrenal medulla, pituitary, and atrium of rat. J. Histochem CR - and Cytochem 33 : 828-832, 1985. CR - 12.Toshimori H Toshimori K Oura G Matsuo H ; Immuno histochemisiry and immunocytochemistry of atrial natriuretic polypeptide in porcine heart. Histochemiştry, 86 : 595-601, 1987. > CR - 13.Toshimori H Toshimori K Oura K Matsüo H ; Immuno histochemical study of atrial natriuretic polypeptides in the embriyonic, fetal and neonafal ral heart. Cell Tissue Res. CR - 248 : 627-633, 1987. CR - 14.Toshimori H Nakazato M Toshimori K : Distribution of atrial natriuretic poly peptide (ANP) - containing cells in the rat heart and pulmonary vein. Cell Tissue Res., 251 : 541- CR - 546, 1988, CR - 15.Toshimeori H Toshimori K Matsukura S : Atrial-Spesific granules in the hearts of normal and deprived rats. Cell Tissue Res, 253 : 547-552, 1988. CR - 16.Wharton J Gulbenkian S5 Merighi A ; Immunohistochemical and ultrastructural localization ol peptid containing nerves and myocardial celis in ihe human at- “ rial CR - appendage. Cell Tissue Res, 254 : 155-166, 1988. UR - https://dergipark.org.tr/en/pub/autfm/issue//1723602 L1 - https://dergipark.org.tr/en/download/article-file/4976114 ER -