TY - JOUR T1 - Serum Beta Microglobulin Levels in Hodgkin and Non-Hodgkin Lymphomas TT - Hodgkin Ve Hodgkin Dışı Lenfomalarda Serum Beta, Mikroglobülin Düzeyleri AU - Konuk, Nahide PY - 1984 DA - June JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 85 EP - 92 VL - 37 IS - 2 LA - en AB - Serum Beta, microglobulin levels have been specified in eleven Hodgkin and fifteen Non-Hodgkin Lymphoma, patients who have never had a treatment. Serum Beta, microglobulin levels have been found significantly different in the Hodgkin and Non-Hodgkin Lympho-“ma groups with respect to the control groups. Both in Hodgkin and Non-Hodgkin Lymphoma subgroups when the extend of the diseasewas considered it was found that while in stages Tandl! there wasn't any difference when compared with the control groups, in stages 11and IV the difference was significant.Our findings showed that serum Beta, microglobulin guantificaion could be used as a significant tumour marker parallel to the extend of the disease in the organism in Hodgkin and Non-Hodgkin Lymphoma. KW - Lymphomas KW - microglobulin level KW - Hodgkin Disease N2 - Hiç tedavi görmemiş 15 Hodgkin dışı lenfoma ve II Hodgkin olgusunun tümünde serum Beta, mikroglobülin düzeyleri tayin edildi.Serum Beta, mikroglobülin düzeyleri Hodgkin ve Hodgkin dışı lenfoma gruplarında, kontrol grubuna göre anlamlı derecede farklı bulundu. Hasta grubunda, hastalığın yaygınlığı dikkate alındığında, hemHodgkin hem de Hodgkin dışı lenfoma alt gruplarında; 1. TI. evre olguları kontrol grubu ile karşılaştırılırsa; bunlar arasında, anlamlı birfark bulunamazken, II. IV. evre olguları arasındaki fark ise anlamlı bulundu.Bulgularımız, serum Beta» mikroglobülin tayininin, Hodgkin ve Hodgkin dışı lenfomalarda, mevcut hastalığın organizmadaki yaygınlığına paralel şekilde anlamlı bir tümör marker'ı olarak kullanılabileceğini göstermektedir. CR - 1. Amlot PL, Adinolfi M : Serum Beta, microglobulin and its prognostic value in Iymphomas. Europ J Cancer 15 : 791-796, 1979. CR - 2. Beggörd I, Bearn AG: 1 solation and properties of a low molecular weight Beta, microglobulin occuring in human biological fluids. J Biol chem 213 : 4095-4103, 1968. CR - 3. Cassuto JP, Erebs BP : Beta, microglobulin, a tumour marker of Iymphoproliferative disorder. Lancet 28 Odi: 950-951, 1978. CR - 4. . Child JA, Speti B : Serum Beta, microglobulin and C-reactive protein in the monitoring of Iymphomas. Cancer ;: 45 : 318-326, 1980, CR - 5. Daver A ve ark : La Beta, microglobuline en pathologie cancereuse. Pathol Biol26 : 335-340, 1978. CR - 6. Eurin PE, Wibell L : The serum levels and urinöry excretion of Beta, microglobulin in appareniyl healty subjects. Scand J Clin Lab Invest 40 : 427, 1980. CR - 7. Karlsson FA ; Physical-chemical properties ol Beta, microglobulin. Immunol Chem 11 : 111-114, 1974. CR - 8. Karlsson FA, Wibell L, Eurin PE : Beta, microglobulin in clinical medicine. Scand -J Clin Lab Invest 40 : 427, 1980. CR - 9. Nakao Y ve ark ; Genetic and clinical studies of serum Beta, microglobulin levels in haematological malignancies. Clin Exp Immunol. 46 ; 134-141, 1981. CR - 10. Neauport-Saute's C, Bismuth A : Relationship between HLA antigens and Beta, microglobulin as studied by immunofluorescence on the Iymphocyte membrane, J Exp Med. 139 : 957-968, 1974. CR - 11. Nilsson K, Eurin PE, Welsh KL : Production of Beta, microglobulin by normal and malignant human cell lines and peripheral Iymphocytes. Transpl Rev. 21: 53-84, 1974. CR - 12. Poulik MD, Bernoco M : Aggregation of HLA antigens at the Iymphocyte surface induced by antiserum to Beta, microglobulin, Sci 182 : 1352-1355, 1973. CR - 13. Revillard JP, Vincert.C ; La Beta, microglobuline en pathologie. Path Biol. 26 : 279-281 ,1978. 14. Solheim BG, Thorsby E : Böla, mmicroglobulin; part of the HLA molecule in the cell membrane. Tissue antigens 4 : 83-94, 1974, CR - 15. Spati B, Cooper EH, Child JA ; Beta, microglobulin in Iymphoproliferative disorder. Lancet 21 Oct: 897-898, 1978. CR - 16. Wintrobe M ; Clinical haematology, Eight edition, Lea and Febiger PP ; 1648-1719 Philadelphia 1981. UR - https://dergipark.org.tr/en/pub/autfm/issue//1725989 L1 - https://dergipark.org.tr/en/download/article-file/4986103 ER -