TY - JOUR T1 - Mide Ve Duedenum Ülseri Bulunan Hastalarda Mide Suyundaki Prostaglandin Miktarı TT - PROSTAGLANDIN AMOUNT IN GASTROINTESTINAL JUICE IN PATIENTS WITH STOMACH AND DUODENAL ULCERS AU - Alptuna, Erdem PY - 1981 DA - August JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 51 EP - 56 VL - 34 IS - 1 LA - tr AB - Duodenum ülseri bulunan hastalarımızda mide suyundaki PGE.'ye benzer aktivite seviyeleri kontrol gurubuna göre düşük bulunmuştur, Ancak bu düşüklük istatistiki bakımdan anlamlı değildir. Bu nedenle oral kullanılan pristaglandin'in duodenum ülserlilerde PG yetersizliğini gidermek yoluyla etkili olması beklenemez, Mide ülseri bulunan hastalarda ise mide suyundaki PGE,'ye benzer aktivite kontrol ve duodenum ülserli hasta grubuna göre yüksek bulunmuştur. KW - Duodenum ülseri KW - mide suyu KW - pristaglandin N2 - In the gastric juice of duodenal ulcer patients GPE,- like activity Was İower than in controls. The difference was not statisticaly importent, Therefore orally used PG's should not beecpected to treat PG deficiency and hence duodenal ulcer. PGE,-like activity was higher in gastric ulcer patients when compared With duode- nal ulcer patients and control. CR - 1, Bennett A, Fleshler B : Prostaglandins and the gastrointestinal tract, Gastroenteroloji 12 790, 1970 CR - 2. Bennett A, Murray JG, Wyllie JH : Occurrence of prostaglandin E2 in the human stomach and a study of its effect on human isolated muscle, Br J Pharm Chemo 32 339, 1968 CR - 3. Bennett A, Stamford IF, Unger WG : Prostaglandin Ep and gastric acid secretion in amn, J Physi01 229 : 349, 1973 CR - 4. Bennett A, Stamford IF, Unger WG : PGE2 and gastric acid secretion in man Adv Biosci, 9 : 265, 1973 CR - 5. Chen F, H, Karim S : The effect of 15 (R) methyl prostaglandin Eg on gastric acid Secretion in duodenal ülcer patientiens, Prostagladins 13 : IIS, 1977 CR - 6. Coeeani F ve ark : Effect of nerve stimulation on prostaglandin formation and release from the rat stomach Amer J Phys 213 : 1056, 1967 CR - 7. Fung wp, Karim SMM, Tye CY : Effect of 15 (R) 15 methÿ prostaglandin E2 methl ester on healing of gastric ulcers, Lancet 2 : 10, 1974 CR - 8. Fung WI', Lee SK, Karim SMM : Effect of prostaglandin 15 (R) 15 methyl-Eg metyl ester on the gastric mucosa in patiens with peptic ulceration. An endoscopis and his. tolojical study, Prostaglandins 5 : 465, 1974 CR - 9. Hansson E, Sammuelson B : Autoradiographie distrubîtion studies of Ha-Labelled pros taglandin E in micç, Biochim Biophys Acta 106 379, 1965 CR - 10, Hinsdale JG, Engel JJ, Wüson DE : Prostaglandin E in peptic ulcer dísease, Prostaglandins 6 : 495, 1974 CR - 11. Horton EW,Ate ark : Effect of orall administered prostaglandin El on gastric secretion and gastrointestinal motility in man, Gut 9 655, 1968 CR - 12. Nylander B, Anderson S : Effect of two methylated prostaglandin El analogs on duodenal pressure in man, Scan J Gastroenteroloji, 10 : 91, 1975 13. Robert A, Effect of prostaglandins on the stomach and intestine. Prostaglandins 6 : 523, 1974 CR - 14. Sehultz AR, Nezamis JE, Lancaster C : Gastric antisecretory and antiulcer proporties of PGEp, 15-methyl PGE2 and 16, 16 dimethyl PGE2 intravenous oral and intrajejunal administration., Gastroenterology 70 : 359, 1976 CR - 15. Tonnesen MG, ve ark Circadian variation of prostaglandin E(PGE) production in human gastric juice, Dig Dis 19 : 644, 1974 CR - 16, Vane JR : A sensitive method for the assay of 5-dydroxtrltamine, Brit J Pharmacol 12 : 344, 1957 CR - 17. Vane JR ; The use of isolated organs for detecting active substances in the circulating blood, Brit J Pharma 23 : 260, 1964 CR - 18. Wilson DE, ve ark : Effect on an orally administered prostaglandin analogue (16,16-di methy prostagandin Ea) on human gastric secretion, Gastroenterology 69 : 607, 1975 UR - https://dergipark.org.tr/en/pub/autfm/issue//1726432 L1 - https://dergipark.org.tr/en/download/article-file/4987664 ER -