TY - JOUR T1 - Identification of Mitochondrial-Related Genes as Potential Biomarkers for Docetaxel-Resistant Prostate Cancer AU - Hekmatshoar, Yalda PY - 2025 DA - July Y2 - 2025 DO - 10.4274/atfm.galenos.2025.82957 JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 137 EP - 143 VL - 78 IS - 2 LA - en AB - Objectives: Prostate cancer (PC) is the most common cancer among men worldwide and a significant cause of cancer-related deaths. Docetaxel (DX), a taxane-based chemotherapeutic agent, was the first treatment to exhibit substantial efficacy in the management of PC. This study aims to demonstrate the mitochondrial genes that are affected by DX in PC using bioinformatics analysis.Materials and Methods: For bioinformatics analysis, mRNA microarray data from DX-sensitive PC cell lines (DU145) and DX-resistant cell lines (DU145-DR), corresponding to the study GSE36135, were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were analyzed and identified using the Transcriptome Analysis Console 4.0 (TAC). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to pinpoint significant genes and biological pathways associated with DX therapy. Additionally, proteinprotein interaction network analysis was conducted to identify critical proteins and interactions within these pathways.Results: TAC applied criteria of an adjusted p-value KW - : Prostate cancer KW - docetaxel KW - bioinformatics KW - gene expression omnibus KW - gene expression CR - 1. van Dessel LF, van Riet J, Smits M, et al. The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact. Nat Commun. 2019;10:5251. CR - 2. Le TK, Duong QH, Baylot V, et al. Castration-resistant prostate cancer: from uncovered resistance mechanisms to current treatments. Cancers (Basel). 2023;15:5047. CR - 3. 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