TY - JOUR T1 - Fokal Glomerüler Skleroz:Klinik, Laboratuvar,Patolojik Bulgular, Tedavi Ve Prognozu(20 Olgu Nedeniyle) TT - Focal Glomerular Sclerosis: Clinical, Laboratory, Pathological Findings, Treatment and Prognosis (20 Cases) AU - Tümer, Necmiye PY - 1978 DA - September JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 672 EP - 680 VL - 31 IS - 3 LA - en AB - This study evaluates the clinical, laboratory, and pathological findings, treatments, and prognosis of 20 pediatric patients diagnosed with focal glomerular sclerosis. Most cases presented with edema, proteinuria, microscopic hematuria, and resistance to steroid therapy. Progressive deterioration in renal function and the need for hemodialysis were observed in several patients. Notably, earlier renal impairment was found in patients who initially presented with hypertension and hematuria. In light of the literature, focal glomerular sclerosis is emphasized as a poor-prognosis entity, underlining the importance of early diagnosis and differential assessment. KW - Focal glomerular sclerosis KW - nephrotic syndrome KW - proteinuria KW - microscopic hematuria KW - renal failure KW - steroid resistance KW - pediatric nephrology N2 - Bu çalışmada, fokal glomerüler skleroz tanısı konmuş 20 çocuk hastanın klinik, laboratuvar ve patolojik bulguları, uygulanan tedaviler ve hastalığın prognozu değerlendirilmiştir. Vakaların çoğunda ödem, proteinüri, mikroskopik hematüri ve steroid tedavisine direnç gözlenmiştir. Hastalığın ilerleyen dönemlerinde böbrek fonksiyonlarında bozulma ve bazı vakalarda hemodiyaliz gereksinimi ortaya çıkmıştır. Ayrıca, başlangıçta hipertansiyon ve hematüri bulunan hastalarda böbrek fonksiyonlarının daha erken bozulduğu saptanmıştır. Literatür bulguları ışığında, fokal glomerüler sklerozun kötü prognozlu bir antite olduğu ve erken tanı ile ayırıcı tanısının önem taşıdığı vurgulanmıştır. CR - Arneil, G.C. : The Nephrotic Syndrome. Pediatr. Clin. N. Am. 18 : 547, 1971. CR - Arneil, G.C. : Treatment of the Nephrosis with Predisolone. Lancet. 4 : 409 1956. CR - Barratt, T.M., Osofsky, S.G., Bercowsky, As, Soothill, J.F. : Cyclophosphamide Treatment in steroid - Sensitive Nephrotic Syndrome of Childhood. Lancet. 1 • 55, 1975. CR - Berger, J. Yaneva, H., Hinglais, H., Hinglais, N. : Immunohistochemistry of Flomerulonephritis. Year Book Med. Publ. 11, 1971 CR - Churg, J., Habib, R., White, R.H.R. : Pathology of the Nephrotic Syndrome in Children. Lancet. 6 : 20, 1970. CR - Cornfeld, D, Schwarts, M.W. : Nephrosis. A Long-Term Study of Children Treated with Corticosteroids. J. Pediatr. 68 • 507, 1966. CR - Glasgow, E.F. White, R.H.R. : «Not so Minimal». Nephron. 8 : 403, 1971. CR - Habib, R. : Focal Glomerular Sclerosis. 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