TY  - JOUR
T1  - Evaluation of the anti-inflammatory effect of chromium picolinate in methotrexate induced nephrotoxicity rat model
AU  - Hassan, Ali Faris
AU  - Farhan, Jehan Najm Aldeen
PY  - 2025
DA  - July
Y2  - 2024
DO  - 10.12991/jrespharm.1734542
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 1608
EP  - 1615
VL  - 29
IS  - 4
LA  - en
AB  - Methotrexate is a folate antimetabolite chemical used to treat many forms of cancer and cleared mainly by kidney which result in a nephrotoxicity as a major complication of methotrexate. Trivalent chromium complex, chromium picolinate (CrPic), is mostly utilized to regulate glucose and raise insulin sensitivity—particularly in diabetes. The objective of this study was to assess the renoprotective effects of Chromium in mitigating nephrotoxicity induced by Methotrexate in rats. Study conducted on 32 male rats divided into 4 groups; Group I (Control group) in which rats received distilled water orally for 8 days, Group II (Induction group) which received a single intraperitoneal injection of Methotrexate (20 mg/kg) on the first day Followed by distilled water for 7 days, Group III (Chromium 2mg) which received a single intraperitoneal injection of Methotrexate (20 mg/kg) on the first day Followed by CrPic at a dose (2mg/kg) orally for 7 days and finally group IV which is similar to Group III except that the dose of CrPic is 4mg/kg. The levels of creatinine, Kidney Injury Molecule-1 (KIM-1), interleukin 1 beta (IL-1β), and tumor necrosis factors-α (TNF-α) were evaluated for all studied groups and the results showed that the administration of CrPic caused a significant decrease (p
KW  - Interleukin-1 beta
KW  - tumor necrosis factors
KW  - kidney injury molecule-1
KW  - methotrexate induced
nephrotoxicity
KW  - chromium picolinate
KW  - tumor necrosis factor-alpha
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UR  - https://doi.org/10.12991/jrespharm.1734542
L1  - https://dergipark.org.tr/en/download/article-file/5021791
ER  -