TY  - JOUR
T1  - Development and ın vitro characterization of embelin bilosomes for enhanced oral bioavailability
AU  - Sanap, Dhanashree
AU  - Firake, Shreya
AU  - Pethani, Devanshi
AU  - Patil, Jeet
AU  - Bhujbal, Avinash
AU  - Gondake, Rahul
AU  - Agrawal, Sneha
PY  - 2025
DA  - July
Y2  - 2024
DO  - 10.12991/jrespharm.1734545
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 1616
EP  - 1626
VL  - 29
IS  - 4
LA  - en
AB  - The goal of this study was to formulate a nanotechnology-based system incorporating surfactants, cholesterol (CHL), and sodium deoxycholate (SDC) and optimization was done using central composite design of design-expert® software. The variables used were X1 (Surfactant; Span 80) and X2 (Bile salt; SDC). In vitro, release kinetics assessment of the drug revealed an increase in drug release of the drug. Transmission electron microscopy (TEM) exhibited a round shape of developed bilosomes with few having rough surfaces. Fourier Transform Infrared Spectroscopy (FT-IR) data exhibited no specific physiochemical interaction between active and additives. Differential scanning calorimetry (DSC) studies showed the molecular state and the indication of no interactions among the formulation ingredients. The mean vesicle size, polydispersity index, zeta potential, and entrapment efficiency (%) of optimized bilosome formulation were observed to be 211.1 nm, 0.513, 47.8 mV, and 99.664 % respectively. Overall, the obtained results confirmed that Embelin-loaded bilosome could be promising for oral drug delivery.
KW  - Embelin
KW  - bilosomes
KW  - nanocarriers
KW  - anti-microbial
KW  - entrapment efficiency
KW  - zeta potential
KW  - particle size
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UR  - https://doi.org/10.12991/jrespharm.1734545
L1  - https://dergipark.org.tr/en/download/article-file/5021809
ER  -