TY  - JOUR
T1  - Determination of the antimicrobial and antibiofilm activity of lyophilized cornelian cherry (Cornus mas L.)
AU  - Rayaman, Erkan
AU  - Çelik, Zehra Margot
AU  - Kurt, Kadriye
AU  - Albayrak, Miraç
AU  - Akpınar, Oktay
AU  - Emre, Gizem
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.12991/jrespharm.1734691
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 1542
EP  - 1550
VL  - 29
IS  - 4
LA  - en
AB  - This study investigates the antimicrobial and antibiofilm activities of lyophilized Cornelian cherry (Cornusmas L.) and its methanol extract against a range of clinically significant pathogens. The research aimed to evaluate thepotential of these natural compounds as alternative antimicrobial agents, given the global rise in antimicrobialresistance. Antibacterial activity was assessed using agar well diffusion and broth microdilution methods, whileantibiofilm efficacy was determined through biofilm inhibition assays. The methanol extract exhibited broad-spectrumantibacterial activity, effectively inhibiting all tested bacterial strains, whereas the lyophilized form demonstrated noactivity against Klebsiella pneumoniae and Escherichia coli. Both forms showed strong biofilm inhibition, particularlyagainst Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa, and Acinetobacterbaumannii, with inhibition increasing in a dose-dependent manner and peaking at the minimum inhibitoryconcentration. No antifungal activity was observed against the tested Candida species. The superior efficacy of themethanol extract may be attributed to a higher concentration of phenolic and anthocyanin compounds. These findingssuggest that Cornelian cherry, particularly in its methanol-extracted form, holds promise as a natural antimicrobial andantibiofilm agent. Further research is warranted to explore its potential applications in clinical and industrial settings.
KW  - Cornelian cherry
KW  - Cormus mas L.
KW  - antimicrobial effect
KW  - antibiofilm effect
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UR  - https://doi.org/10.12991/jrespharm.1734691
L1  - https://dergipark.org.tr/en/download/article-file/5022362
ER  -