TY - JOUR T1 - Anestezik İlaçların Biyotransformasyonu ve Uygulama Yönünden Yeni Görüşler TT - New Views On The Biotransformation Of Anesthetic Drugs And Their Application AU - Paykoç, Refik PY - 1975 DA - June JF - Ankara Üniversitesi Tıp Fakültesi Mecmuası PB - Ankara University WT - DergiPark SN - 0365-8104 SP - 449 EP - 458 VL - 28 IS - 1-2 LA - tr AB - Anestezi uygulamasında anestezik aianlara karsl anormal reaksiyonlarln görülmesi nadir dežildir. Bu reaksiyonlar araslnda klinik önemi olanlar halotan hepatotoksisitesi, methoxyflurane nefrotoksisitesi ve malign hipertermidir.Bu makalede anestezik maddelerin biyotransformasyonunda yeni görüsler ve bunun klinik uygulamaya olan etkisi izah edilmege çall}llmaktadlr. Bugün için anestezik maddelere karsl görülen anormal reaksiyonlarln metabolik etki ile izahl geçerli bir hipotez gibi görülmektedir. KW - ANESTEZİK İLAÇLAR KW - BİYOTRANSFORMASYON KW - ANESTEZİ N2 - Unusual reaction to anesthetic agents is not a rare entity in Practice of Anesthesia some of the clinically important reactions include Halothane Hepatotoxicity, Methoxyflurane Nefrotoxicity and the malignant Hyperthermia.In this article new concepts of anesthetic biotransformation and its application to clinical practice is explained. For the time being, the effects of metabolism on clinical toxicity of genera] anesthetic agents seems like a valid hypothesis. CR - 1 Airaksinen, M. M., Tammisto, T. : Toxic actions of the metabolites of Halothane LDs-IO and some metabolic effects of trifluoroethanol and trifluoroacetic acid in mice and guinea pigs. Ann. Med. Eh'P. Fenn., 46 242 -248, 1968. CR - 2 — Belfrage, S., Ahlgren, 1., Axelson, S. : Halothane hepatitis in an anesthetist. Lancet, 11 : 1466 - 1467, 1966. CR - 3 Berman, M. L., Bochantin, J. Nonspecific stimulation of drug metabolism in rats by Methoxyflurane. 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