TY  - JOUR
T1  - Administration of Preoperative Meloxicam and Firocoxib on Postoperative Analgesia and Inflammatory Markers in Dogs Undergoing Ovariohysterectomy
TT  - Ovariohisterektomi Öncesinde Köpeklerde Preoperatif Meloksikam ve Firokoksibin Uygulamasının Postoperatif Analjezi ve İnflamatuvar Belirteçler Üzerine Etkisi
AU  - Güner, Barış
AU  - Şahin, Osman Alp
AU  - Öztürk, Buse
AU  - Ayalp, Aslıhan
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.53424/balikesirsbd.1740346
JF  - Balıkesir Sağlık Bilimleri Dergisi
JO  - BAUN Health Sci J
PB  - Balıkesir University
WT  - DergiPark
SN  - 2146-9601
SP  - 772
EP  - 780
VL  - 14
IS  - 3
LA  - en
AB  - Objective: The objective of this study was to evaluate the postoperative analgesic and anti-inflammatory effects of meloxicam and firocoxib in dogs undergoing ovariohysterectomy (OHE). Materials and Methods: Thirty healthy female dogs were randomly assigned to three groups: 0.2 mg/kg subcutaneous meloxicam, 5 mg/kg oral firocoxib, or no preoperative non-steroidal antiinflammatory drug (control). The Glasgow Composite Measure Pain Scale – Short Form (CMPS-SF), rectal temperature, and heart rate were recorded preoperatively and at 1, 2, 3, 4, and 24 hours postoperatively. Blood samples were collected at each time point to assess cortisol levels and calculate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). Results: CMPS-SF scores significantly increased at 1 hour postoperatively in all groups (p
KW  - dog
KW  - firocoxib
KW  - meloxicam
KW  - NLR
KW  - pain
N2  - Amaç: Bu çalışmanın amacı, ovariohisterektomi (OHE) uygulanan köpeklerde meloksikam ve firokoksibin postoperatif analjezik ve anti-inflamatuvar etkilerini değerlendirmektir. Materyal ve Yöntem: Otuz sağlıklı dişi köpek rastgele üç gruba ayrıldı: 0.2 mg/kg subkutan meloksikam, 5 mg/kg oral firokoksib veya preoperatif nonsteroid anti-inflamatuar ilaç uygulanmayan kontrol grubu. Glasgow Bileşik Ağrı Ölçeği – Kısa Formu (CMPS-SF), rektal sıcaklık ve kalp atım hızı operasyon öncesinde ve postoperatif 1., 2., 3., 4. ve 24. saatlerde kaydedildi. Aynı zaman dilimlerinde kan örnekleri alınarak kortizol düzeyleri ile nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) ve sistemik immün-inflamasyon indeksi (SII) değerlendirildi. Bulgular: CMPS-SF skorları postoperatif 1. saatte tüm gruplarda anlamlı şekilde arttı (p
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UR  - https://doi.org/10.53424/balikesirsbd.1740346
L1  - https://dergipark.org.tr/en/download/article-file/5046389
ER  -