TY  - JOUR
T1  - The Effects of Taurine on Energy Homeostasis and Health: A Nutritional Perspective
TT  - Taurinin Enerji Homeostazi ve Sağlık Üzerindeki Etkileri: Beslenme Perspektifi
AU  - Dağoğlu Polat, İrem
AU  - Baran, Özlem
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.25048/tudod.1744454
JF  - Turkish Journal of Diabetes and Obesity
JO  - Turk J Diab Obes
PB  - Zonguldak Bulent Ecevit University
WT  - DergiPark
SN  - 2587-0335
SP  - 136
EP  - 146
VL  - 9
IS  - 2
LA  - en
AB  - Taurine is a sulfur-containing β-amino acid that structurally differs from standard amino acids. It is found in high concentrationsacross various tissues of the human body and plays a role in numerous physiological processes, including antioxidant defense, energyregulation, and modulation of the central nervous system. Globally increasing obesity is accompanied by serious health problems suchas metabolic syndrome, insulin resistance, dyslipidemia, and hyperglycemia. While traditional approaches have regarded adipose tissueas a passive structure solely involved in lipid storage, it is now recognized as an active endocrine organ. In this context, the biologicallyactive molecules secreted by adipocytes and their roles in metabolic processes are critically important in the pathogenesis of obesity.The primary aim of this review article is to systematically evaluate the functional effects of taurine in adipose tissue and the mechanismsby which it counteracts obesity. Taurine possesses a structure that distinguishes it from typical amino acids and is present in highconcentrations in the body, contributing to various biological functions such as reducing oxidative stress, suppressing inflammation,and regulating energy metabolism. Studies in animal models have demonstrated that taurine supplementation reduces inflammationin adipose tissue, increases lipolysis, activates thermogenic pathways, and suppresses appetite via central nervous system mechanisms, thereby preventing the development of obesity. Moreover, findings of low plasma taurine levels in individuals living with obesity anddiabetes suggest that taurine deficiency may disrupt metabolic balance. Although animal and epidemiological studies indicate thattaurine is promising for alleviating metabolic disorders, further advanced research is necessary to fully elucidate its mechanisms andconfirm its efficacy in humans
KW  - Adipose Tissue
KW  - Obesity
KW  - Taurine
N2  - Taurin, standart amino asitlerden yapısal olarak farklılık gösteren, sülfür içeren bir β-amino asittir. İnsan vücudunun çeşitli dokularındayüksek konsantrasyonlarda bulunur ve antioksidan savunma, enerji regülasyonu ve merkezi sinir sisteminin düzenlenmesi gibi çoksayıda fizyolojik süreçte rol alır. Küresel olarak artan obeziteye metabolik sendrom, insülin direnci, dislipidemi ve hiperglisemi gibiciddi sağlık sorunları eşlik etmektedir. Geleneksel yaklaşımlar yağ dokusunu sadece lipid depolamada rol alan pasif bir yapı olarakgörürken, artık aktif bir endokrin organ olarak kabul edilmektedir. Bu bağlamda, adipositler tarafından salgılanan biyolojik olarak aktifmoleküller ve bunların metabolik süreçlerdeki rolleri obezitenin patogenezinde kritik öneme sahiptir. Bu derleme makalesinin temelamacı, taurinin adipoz dokudaki fonksiyonel etkilerini ve obeziteye karşı koyma mekanizmalarını sistematik olarak değerlendirmektir.Taurin, onu tipik amino asitlerden ayıran bir yapıya sahiptir ve vücutta yüksek konsantrasyonlarda bulunur, oksidatif stresi azaltmak,inflamasyonu bastırmak ve enerji metabolizmasını düzenlemek gibi çeşitli biyolojik işlevlere katkıda bulunur. Hayvan modellerindeyapılan çalışmalar, taurin takviyesinin yağ dokusundaki enflamasyonu azalttığını, lipolizi artırdığını, termojenik yolları aktive ettiğini vemerkezi sinir sistemi mekanizmaları yoluyla iştahı baskıladığını ve böylece obezite gelişimini önlediğini göstermiştir. Ayrıca, obezite vediyabetle yaşayan bireylerde düşük plazma taurin düzeylerinin saptanması, taurin eksikliğinin metabolik dengeyi bozabileceğine işaretetmektedir. Her ne kadar hayvan ve epidemiyolojik çalışmalar taurinin metabolik bozuklukları hafifletmek için umut verici olduğunugösterse de, mekanizmalarını tam olarak aydınlatmak ve insanlardaki etkinliğini doğrulamak için daha ileri araştırmalara ihtiyaç vardır.
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UR  - https://doi.org/10.25048/tudod.1744454
L1  - https://dergipark.org.tr/en/download/article-file/5063441
ER  -