TY - JOUR T1 - Prognostic value of left ventricular remodelling phenotypes in patients undergoing transcatheter aortic valve implantation TT - Transkateter aort kapak implantasyonu sonrasında sol ventrikül yeniden şekillenme paternlerinin ters yeniden şekillenme ve klinik sonuçlar üzerindeki etkisi AU - Güney, Murat Can PY - 2025 DA - September Y2 - 2025 DO - 10.32322/jhsm.1746396 JF - Journal of Health Sciences and Medicine JO - J Health Sci Med /JHSM /jhsm PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2636-8579 SP - 839 EP - 846 VL - 8 IS - 5 LA - en AB - Aims: This study aimed to evaluate the impact of baseline left ventricular (LV) remodeling phenotypes on clinical and echocardiographic outcomes in patients undergoing transcatheter aortic valve implantation (TAVI).Methods: A total of 413 patients with aortic stenosis (AS) who underwent TAVI between July 2011 and January 2024 were retrospectively analyzed. Based on echocardiographic parameters, patients were classified into concentric remodeling (CR, 7%), concentric hypertrophy (CH, 84.5%), and eccentric hypertrophy (EH, 8.5%) groups.Results: Patients in the EH group were significantly younger (mean age: 76, p KW - Transcatheter aortic valve implantation KW - left ventricular remodeling KW - concentric hypertrophy KW - eccentric hypertrophy KW - permanent pacemaker KW - aortic stenosis N2 - Amaç: Bu çalışmada, transkateter aort kapak implantasyonu (TAVI) uygulanan hastalarda işlem öncesi sol ventrikül (LV) yeniden şekillenme (remodelling) fenotiplerinin klinik ve ekokardiyografik sonuçlar üzerindeki etkisi değerlendirildi.Yöntem: Üç merkezden, Temmuz 2011 ile Ocak 2024 tarihleri arasında TAVI uygulanan ve yeterli ekokardiyografik verisi bulunan toplam 413 hasta retrospektif olarak incelendi. Hastalar; konsantrik yeniden şekillenme (CR, %7), konsantrik hipertrofi (CH, %84.5) ve eksantrik hipertrofi (EH, %8.5) olmak üzere üç gruba ayrıldı.Bulgular: EH grubundaki hastalar daha genç (ortalama yaş: 76, p CR - Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest. 1975;56(1):56-64. doi:10.1172/JCI108079 CR - Cioffi G, Faggiano P, Vizzardi E, et al. Prognostic effect of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis. Heart. 2011;97(4):301-307. doi:10.1136/hrt.2010.192997 CR - Bonow RO, Dodd JT, Maron BJ, et al. Long-term serial changes in left ventricular function and reversal of ventricular dilatation after valve replacement for chronic aortic regurgitation. Circulation. 1988;78(5 Pt 1): 1108-1120. doi:10.1161/01.cir.78.5.1108 CR - Lindman BR, Stewart WJ, Pibarot P, et al. Early regression of severe left ventricular hypertrophy after transcatheter aortic valve replacement is associated with decreased hospitalizations. JACC Cardiovasc Interv. 2014;7(6):662-673. doi:10.1016/j.jcin.2014.02.011 CR - Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011;58(17):1733-1740. doi:10.1016/j.jacc.2011.07.022 CR - Une D, Mesana L, Chan V, et al. Clinical impact of changes in left ventricular function after aortic valve replacement: analysis from 3112 patients. Circulation. 2015;132(8):741-747. doi:10.1161/CIRCULATIONAHA.115.015371 CR - Sato K, Kumar A, Jones BM, et al. Reversibility of cardiac function predicts outcome after transcatheter aortic valve replacement in patients with severe aortic stenosis. J Am Heart Assoc. 2017;6(7):e005798. doi:10. 1161/JAHA.117.005798 CR - Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol. 2012;60(19):1854-1863. doi:10.1016/j.jacc.2012.02.093 CR - Capoulade R, Clavel MA, Dumesnil JG, et al. Insulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial. JACC Cardiovasc Imaging. 2013;6(2):165-174. doi:10.1016/j.jcmg.2012.11.004 CR - Gerdts E. Left ventricular structure in different types of chronic pressure overload. Eur Heart J Suppl. 2008;10(suppl_E):E23-E30. doi:10.1093/eurheartj/sun015 CR - Pibarot P, Dumesnil JG. Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. J Am Coll Cardiol. 2012;60(19):1845-1853. doi:10.1016/j.jacc.2012.06.051 CR - Clavel MA, Berthelot-Richer M, Le Ven F, et al. Impact of classic and paradoxical low flow on survival after aortic valve replacement for severe aortic stenosis. J Am Coll Cardiol. 2015;65(7):645-653. doi:10.1016/j.jacc. 2014.11.047 CR - Rymuza B, Zbroński K, Scisło P, et al. Left ventricular remodelling pattern and its relation to clinical outcomes in patients with severe aortic stenosis treated with transcatheter aortic valve implantation. Postepy Kardiol Interwencyjnej. 2017;13(4):288-294. doi:10.5114/aic.2017.71609 CR - Beach JM, Mihaljevic T, Rajeswaran J, et al. Ventricular hypertrophy and left atrial dilatation persist and are associated with reduced survival after valve replacement for aortic stenosis. J Thorac Cardiovasc Surg. 2014;147(1):362-369.e8. doi:10.1016/j.jtcvs.2012.12.016 CR - La Manna A, Sanfilippo A, Capodanno D, et al. Left ventricular reverse remodeling after transcatheter aortic valve implantation: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2013;15(1):39. doi:10.1186/1532-429X-15-39 CR - Petrov G, Dworatzek E, Schulze TM, et al. Maladaptive remodeling is associated with impaired survival in women but not in men after aortic valve replacement. JACC Cardiovasc Imaging. 2014;7(11):1073-1080. doi: 10.1016/j.jcmg.2014.06.017 CR - Helder MR, Ugur M, Bavaria JE, et al. The effect of postoperative medical treatment on left ventricular mass regression after aortic valve replacement. J Thorac Cardiovasc Surg. 2015;149(3):781-786. doi:10.1016/ j.jtcvs.2014.10.034 UR - https://doi.org/10.32322/jhsm.1746396 L1 - https://dergipark.org.tr/en/download/article-file/5071314 ER -