TY  - JOUR
T1  - Renal Osteodistrofinin Erken Evresinde Kemik Histolojisi ve Mineral Dengesi
TT  - Bone Histology and Mineral Balance in the Early Stage of Renal Osteodystrophy
AU  - Tümer, Necmiye
PY  - 1982
DA  - March
JF  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
PB  - Ankara University
WT  - DergiPark
SN  - 0365-8104
SP  - 157
EP  - 166
VL  - 35
IS  - 1
LA  - tr
AB  - Bu çalışma, kronik böbrek yetmezliğinin radyolojik bulguları ortaya çıkmadan önceki erken evresinde kemik dokusundaki histolojik değişiklikleri ve mineral dengesini incelemektedir. Radyolojik olarak renal osteodistrofi bulgusu olmayan 11 çocuk hastadan alınan kemik biyopsilerinde, lamellerde incelme, atrofi ve kemik yapımında azalma gözlenmiştir. Kemik dokusunda anlamlı şekilde azalmış kalsiyum ve hidroksiprolin düzeyleri saptanırken; fosfor, magnezyum, çinko, bakır ve alkalen fosfataz düzeyleri normal bulunmuştur. Serum ve idrarda kalsiyum değerleri hafif düşük olup, hidroksiprolin ise anlamlı düzeyde azalmıştır. Sonuçlar, kemik yapımındaki azalma ile düşük hidroksiprolin ve kalsiyum düzeyleri arasında pozitif bir ilişki olduğunu ve bu metabolik bozuklukların vitamin D yetersizliği ile yetersiz protein alımına bağlı gelişebileceğini göstermektedir. Radyolojik bulgular oluşmadan önce tanı ve tedaviye başlanmasının önemi vurgulanmaktadır.
KW  - renal
KW  - kemik
KW  - mineral
N2  - This study investigates bone histological changes and mineral balance in the early stages of chronic renal failure—before radiological signs of renal osteodystrophy appear. Bone biopsies from 11 pediatric patients without radiological evidence revealed thinning of bone lamellae, atrophy, and reduced osteogenesis. A significant reduction in calcium and hydroxyproline concentrations was found in bone tissue, while phosphorus, magnesium, zinc, copper, and alkaline phosphatase levels remained within normal ranges. Slightly low serum and urine calcium levels were observed, along with a notable decline in hydroxyproline. The findings demonstrate a positive correlation between decreased bone formation and lowered hydroxyproline and calcium, likely linked to vitamin D deficiency and inadequate protein intake. The study emphasizes the importance of initiating treatment before radiological signs of osteodystrophy manifest.
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UR  - https://dergipark.org.tr/en/pub/autfm/issue//1748051
L1  - https://dergipark.org.tr/en/download/article-file/5078828
ER  -