TY  - JOUR
T1  - Amfetamin'in Sıçanda Meydana Getirdiği Motor Aktivite Artışına 6-Hidroksidopamin ve L-Dopa'nın Etkileri
TT  - Effects of 6-Hydroxydopamine and L-Dopa on Amphetamine-Induced Increase in Motor Activity in Rats
AU  - Ulus, İsmail
PY  - 1971
DA  - December
JF  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
PB  - Ankara University
WT  - DergiPark
SN  - 0365-8104
SP  - 1060
EP  - 1073
VL  - 24
IS  - 6
LA  - tr
AB  - Bu çalışmada, sıçanlarda motor aktivite üzerinde, 6-OHDA ve L-DOPA'nın ayrı ayrı ve müştereken d-amfetaminle etkileşmesini inceledik. Motor aktivite, periton içine d-amfetamin zerkinden 45 dakika sonra 10 dakika süreyle Y labirentinde ölçüldü. d-Amfetamin doza bağlı olarak motor aktiviteyi arttırdı. Spontan motor aktivite, 0.5,1 ve 1.55 mg/kg d-amfetamin injeksiyonlarından sonra sırayla, kontrol cevap olan 4.5x0.5 den 14.772.6,42.6F4.2 ve 54.175.8 e yükseldi. Yalanma ve koklama gibi stere otipik davranışlar 2.5 mg/kg damfetaminle görülmeye başladı. Bu hareketler lokomotor aktiviteyi maskelediği için bu dozda lokomotor aktivitede azalma oldu (Şekil 1).T gün süryle günde 50 mg/kg L-DOPA almış sıçanlarda 1 mg/kg amfetaminin motor aktiviteye olan etkisi kontrollerden düşüktü. (p  < 0.05) (Şekil — 1,2). Denemeden 3 gün önce intracerebroventriküler olarak injekte edilen 250 ug 6-OHDA, i mg/kg d-amfetaminin sıçanlarda motor aktivite üzeriine olan etkisini arttırdı, Spontan motor aktivite 1 mg/kg d-amfetamin ile 37.5-7.5 dan 69.779.1 e yükseldi. (p  < 0.01) bunun zıttı olarak 6-OHDA injeksiyonundan 30 gün sonra Il mg/kg d-amfetaminin yaptığı artış kontrollerden farklı değildi. Yedi gün süreyle günde 50 mg/kg L-DOPA almış sıçanlarda, yedinci gün intracerebroventriküler olarak 250 ug 6-OHDA verilmiş ve üç gün sonra 1 mg/kg amfelamin denendi. Bu sıçanlarda amfetamin cevabı kontrollerden farklı değildi (Şekil 3). Sonuçlar motor aktivite düzenlenmesinde merkezi monoaminerjik sistemin rölü ve ilaçların bu sisteme olan etkileri bakımından tartışıldı.
KW  - Motor aktivite
KW  - 6-OHDA
KW  - L-DOPA
N2  - In the present study, we tested the interaction of 6-OHDA and/or L-DOPA with d-amphetamine on the motor activity of rats. The motor activity was measured in (Y) maze during the 10 minutes, 45 minutes after the injection of amphetamine intraperitonealy. d-Amphetamine sülphate increased the snontaneous motor activity of rats in a dose dependent manner, Spontaneous motor activity increased from a control response of 4.550.5 to 14.752.6, 42.6F4.2 and 54.155.8 after the injection of 0.5, 1 and 1.5 mg/kg d-amphetamine respectively. Stereotyped behaviours such as Ssnif. fing and licking began with 2.5 mg/kg d-ampheamine Stereotyped behaviours masked locomotor activity so that it decreased after 2.5 mg/kg of d-amphetamine (Fig — 1). The effect of 1 mg/kg of d-ampheamine on the motor activity of rats which recievel L-DOPA (50 mg/kg perday for 7 days) was significantiy lower than control animals, (p  < 0.05). 250 ug 6-OHDA, which was injected intracerebroventricularIy three days before the test, caused an increase on the effect of 1mg/kg of d-amphetamine on the motor activity of rats. Spontoneous motor activity increased from 37.5 - 7.5 to 69.7 -9.1 with 1 mg/kg of d-amphetamine. (p
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UR  - https://dergipark.org.tr/en/pub/autfm/issue//1750169
L1  - https://dergipark.org.tr/en/download/article-file/5087817
ER  -