TY  - JOUR
T1  - Akut Promiyelositer Lösemi
TT  - Acute Promyelocytic Leukemia
AU  - Berkol, Bekir
PY  - 1964
DA  - March
JF  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
PB  - Ankara University
WT  - DergiPark
SN  - 0365-8104
SP  - 127
EP  - 133
VL  - 17
IS  - 1
LA  - tr
AB  - 1. Türkiyede ilk defa neşredilmiş olduğu zannedilen akut birpromiyelositer lösemi vak'ası takdim olundu.2. Akut promiyelositer löseminin literatürde önceleri akutmiyeloit lösemi, sonraları bizzat akut promiyelositer lösemi adı ileyayınlanmış olan bir kısım vak'aları özellikleri ile özet olarak bhildirildi.3. Akut promiyelositer lösemiyi karakterize eden ve promiyelositadı verilen hücrelerin özelliklerine işaret edildi. Bu tip lösemidekifibrinojen değişikliklerinin mahiyeti ve hemorajik belirtilerinsebebleri münakaşa edildi. Fibrinojenopeninin bu hastalıkta sabitbir bulgu teşkil ettiği ve bunun trombositopeni ile bir arada kanamadiyatezinin husulünde sorumlu olduğu kanaatı ortaya konuldu
KW  - Akut promiyelositer lösemi
KW  - hipofibrinojenemi
KW  - trombositopeni
KW  - kanama diyatezi
KW  - fibrinoliz
N2  - 1. A case of acute promyelocytic leukemia, believed to be the first to be published in Türkiye, was presented.2. A number of cases of acute promyelocytic leukemia, initially published in the literature as acute myeloid leukemia and later as acute promyelocytic leukemia itself, were summarized.3. The characteristics of the cells called promyelocytes, which characterize acute promyelocytic leukemia, were pointed out. The nature of fibrinogen changes and the causes of hemorrhagic manifestations in this type of leukemia were discussed. It was concluded that fibrinogenopenia is a consistent finding in this disease and that it is responsible for the bleeding diathesis associated with thrombocytopenia.
CR  - 1. Tagnon, H. J.: The occurrence of fibrinolysis in shock, with observations on the prothrombin time and plasma fibrinogen during hemorrhagic shock. Am. J. M. Sc. 211:88, 1946.
CR  - 2. Giraud, G., Gazal, P., Latour, H., Izorn, P., Levy, A., Bargon, P. and Ribstein, M.: Syndrome hemorrhagic mortal par fibrinolysé alguë au cours d’une loucose. Sang 25:628, 1954.
CR  - 3 .Pisciotta, A. V. and Schulz, E. J.: Fibrinolytic purpura in acute leukemia. Am. J. Med. 19:824, 1955.
CR  - 4. Cooperberg, A. A. and Neiman, G. M.: Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia. Ann. Int. Med. 42:706, 1955.
CR  - 5. Hillestad, L. K.: Acute promyelocytic leukemia. Acta med. Scandinav. 159:189, 1957.
CR  - 6. Bernard, J., Mathé, G., Boulay, J., Céoard, B., Chome, J.: La leucose alguë à promyélocytes, Schweiz, med. Wschr. 89:604, 1959.
CR  - 7. Ghitis, J.: Acute promyelocytic leukemia? Blood 21:237, 1963.
CR  - 8. Rosenthal, R. L.: Acute promyelocytic leukemia associated with hypofibrinogenemia. Blood 21:495, 1963.
CR  - 9. Stefanini, M.: Fibrinolysis and fibrinolytic purpura. Blood 7:1044, 1952.
CR  - 10. Risak, E.: Die Fibrinopenie, Ztschr. Kiln. Med. 128:605, 1935.
UR  - https://dergipark.org.tr/en/pub/autfm/issue//1750948
L1  - https://dergipark.org.tr/en/download/article-file/5090764
ER  -