@article{article_1751730, title={Investigation of the protective role of fisetin against doxorubicin-induced liver injury in rats}, journal={The European Research Journal}, volume={11}, pages={1147–1156}, DOI={10.18621/eurj.1751730}, author={Deniz, Ömür Gülsüm}, keywords={Doxorubicin, fisetin, histopathology, liver, rat}, abstract={<p> <b>Objectives: </b> The aim of the present research was to histopathologically investigate the potentially advantageous effects of the flavonoid fisetin on liver damage induced by the chemotherapeutic drug doxorubicin (DOX) in rats. </p> <p> <b>Methods: </b> Thirty-five Wistar albino female rats were randomized in five as Control, dimethyl sulfoxide (DMSO, solvent), fisetin (50 mg/kg/day; 7 days i.p.), DOX (single dose, 10 mg/kg; i.p.) and DOX+fisetin (10 mg/kg DOX+50 mg/kg/day fisetin for 7 days). Livers were harvested, fixed in 10% formalin, and processed for histopathology by hematoxylin-eosin staining. Central to these analyses of damage parameters for inflammation, sinusoidal dilatation, and hepatocyte injury were examined histopathologically. </p> <p> <b>Results: </b> The DOX group had severe hepatocyte degeneration, inflammation, and sinusoidal dilatation. In contrast, the DOX+fisetin group expressed mild sinusoidal dilatation and insignificant inflammatory change. In this context, statistical significance was found between the DOX group and the DOX+fisetin group in terms of hepatocyte degeneration and inflammation (P<0.01), and sinusoidal dilatation (P=0.038). However, no significant differences were observed in between the Control, fisetin, and DMSO groups (P=1.000). </p> <p> <b>Conclusions: </b> Fisetin conferred substantial histological protection from DOX-induced liver injury in rats. The amelioration may have resulted from the fisetin’s antioxidant, anti-inflammatory, and perhaps membrane-stabilizing effects, thus proving its potential as a hepatoprotective agent. </p>}, number={6}, publisher={Prusa Medical Publishing}