TY  - JOUR
T1  - Evaluation of the Antioxidant Activity of the Aqueous Extract of Rosa Sempervirens Leaves in Association with Saliva
AU  - Moualek, Idir
AU  - Benarab, Karima
AU  - Mouhous, Azeddine
AU  - Cherfouh, Rabia
AU  - Djellal, Farid
AU  - Bouzourene, Ali
AU  - Houali, Karim
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.55549/epstem.1753145
JF  - The Eurasia Proceedings of Science Technology Engineering and Mathematics
JO  - EPSTEM
PB  - ISRES Publishing
WT  - DergiPark
SN  - 2602-3199
SP  - 43
EP  - 48
VL  - 34
LA  - en
AB  - Rosa sempervirens, a perennial climbing shrub, is renowned for its significant antioxidantproperties, primarily due to its rich polyphenolic content. The interaction between plant extracts and biologicalfluids such as saliva is a relatively unexplored area that could have substantial implications for thebioavailability and effectiveness of bioactive compounds. Saliva, as the first biological medium encounteredduring oral intake, may influence the structure and functionality of these compounds.This study aims to evaluatethe impact of the association between the aqueous extract of Rosa sempervirens and human saliva on the plant’santioxidant potential. By examining this interaction, the research seeks to understand whether the salivaryenvironment affects the absorption, structural integrity, or bioactivity of the extract’s polyphenols. Theantioxidant capacity of the extract, both before and after exposure to saliva, was assessed through various invitro assays.Results revealed that the association between Rosa sempervirens extract and saliva demonstrated apotent DPPH radical scavenging activity with an IC50 value of 3.808 ± 0.126 μg/ml. The hydroxyl radical (OH)scavenging and hydrogen peroxide (H2O2) scavenging activities were measured, yielding IC50 valuesof 459.2 ± 0.126 μg/ml and 41.68 ± 0.126 μg/ml, respectively. The ferrous ion chelating activity presented anIC50 of 1064.159 ± 0.126 μg/ml, indicating moderate chelation capability. The ferric reducing antioxidantpower (FRAP) and total antioxidant capacity (TAC) assays further validated the antioxidant efficacy of theassociation, with IC50 values of 47.5 ± 0.126 μg/ml and 358.2 ± 0.126 μg/ml, respectively.These resultsunderscore the potential influence of saliva on the antioxidant properties of Rosa sempervirens extract,highlighting the need to consider the oral phase in the evaluation of polyphenol-rich plant extracts. Further investigation into the biochemical pathways of these interactions could provide new insights into optimizing thetherapeutic applications of Rosa sempervirens in antioxidant therapies
KW  - Rosa sempervirens
KW  - Saliva ınteractions
KW  - Antioxidant activity
KW  - Polyphenols
KW  - Radical scavenging
KW  - Traditional medicine
CR  - Moualek, I., Benarab, K., Kadi, S.A., Mouhous, A., Cherfouh, R., Djellal, F., Bouzourene, A., & Houali, K.  (2025). Evaluation of the antioxidant activity of the aqueous extract of rosa sempervirens leaves in association with saliva. The Eurasia Proceedings of Science, Technology, Engineering and Mathematics (EPSTEM), 34, 43-48.
UR  - https://doi.org/10.55549/epstem.1753145
L1  - https://dergipark.org.tr/en/download/article-file/5100391
ER  -