@article{article_1756366, title={The effect of filgrastim on hemodynamic parameters in naive rats}, journal={Anatolian Current Medical Journal}, volume={7}, pages={733–737}, year={2025}, DOI={10.38053/acmj.1756366}, author={Çalışkan, Hasan and Koçak, Seda and Nalçacı, Erhan}, keywords={Blood pressure, filgrastim, heart rate, neutropenia}, abstract={Aims: Filgrastim, a recombinant form of granulocyte colony-stimulating factor (G-CSF), is used in neutropenic conditions. Apart from its use in neutropenia treatment, it is also employed in experimental studies due to its neuroprotective effects. This study aimed to investigate the effect of filgrastim on hemodynamic parameters in rats. Methods: 24 adult male Wistar albino rats were used. The rats were divided into three groups: control, 50 μg filgrastim group, and 100 μg filgrastim group (n=8). Filgrastim was administered intraperitoneally once daily in a dose-dependent manner for a total of 5 days. The control group received 1 ml/kg of saline, following a similar treatment protocol. After 5 days of filgrastim administration, blood pressure measurements were taken in all groups of rats using indirect tail-cuff plethysmography. A total of five measurements were taken at 1-minute intervals for each animal. Results: Systolic pressure (control: 117.40±7.93 mmHg, 50μg: 118.50±17.25 mmHg, 100 μg: 127.70±14.94 mmHg), diastolic pressure (control: 92.42±8.76 mmHg 50 ug: 95.65±8.75 mmHg, 100 μg: 101.20±8.04 mmHg) and mean arterial pressure (control: 100.70±7.61 mmHg 50μg: 103.20±10.62 mmHg 100 μg: 110.00±9.91 mmHg) were not significantly different among experiment groups (p>0.05). Heart rates showed a remarkable increase in the group administered 100 μg (366.5±22.35) compared to the control group, while no significant increase was observed in the group administered 50 μg (348±15.69). Conclusion: In our study, no consistent changes in systolic blood pressure were observed across treatment groups. However, a modest increase in heart rate was observed at the higher dose, suggesting a potential dose-related cardiovascular effect after 5 days of Filgrastim administration. Long-term effects of similar and higher doses on hemodynamic parameters can be examined.}, number={6}, publisher={MediHealth Academy Yayıncılık}, organization={Expenditures, including drugs and chemicals, did not receive specific grants from public, commercial, or not-for-profit funding agencies. Only animal prices were provided by the Council of Higher Education Faculty Member Training Program.}