TY  - JOUR
T1  - High alkaline phosphatase level in a healthy child: A case of benign transient hyperphosphatasemia
TT  - Yüksek alkalen fosfataz değeriyle başvuran sağlıklı bir çocuk: benign geçici hiperfosfatazemi olgusu
AU  - Kasap, Tolga
AU  - Tekin, Samet Can
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.55665/troiamedj.1767889
JF  - Troia Medical Journal
JO  - Troia Med J
PB  - Çanakkale Onsekiz Mart University
WT  - DergiPark
SN  - 2630-6107
SP  - 97
EP  - 99
VL  - 6
IS  - 3
LA  - en
AB  - Benign transient hyperphosphatasemia (BTH) is a self-limited condition of early childhood, defined by a transient elevation of serum alkaline phosphatase (ALP) without evidence of underlying disease. This report emphasizes the importance of considering BTH in the differential diagnosis of elevated ALP and presents a case in light of the current literature. Recognition of BTH is crucial to prevent unnecessary investigations and referrals in pediatric practice.
KW  - Benign transient hyperphosphatasemia
KW  - children
KW  - alkaline phosphatase
N2  - Benign geçici hiperfosfatazemi (BGH), erken çocukluk döneminde görülen, altta yatan herhangi bir hastalık bulgusu olmaksızın serum alkalen fosfataz (ALP) düzeylerinde geçici yükselme ile karakterize, kendini sınır- layan bir durumdur. Bu olgu sunumu, artmış ALP düzeylerinin ayırıcı tanısında BGH’nin göz önünde bulun- durulmasının önemini vurgulamakta ve mevcut literatür ışığında bir olguyu sunmaktadır. BGH’nin tanınması, çocukluk çağında gereksiz tetkik ve yönlendirmelerin önlenmesi açısından büyük önem taşımaktadır.
CR  - 1. Solé-Enrech G, Cano-Corres R, Nuez-Zaragoza E, Pine- da-Solas V, Berlanga-Escalera E. Benign transient hyperp- hosphatasemia: Two case reports. Clin Biochem. 2021 May;91:67-69. 
doi: 10.1016/j.clinbiochem.2021.01.015. Epub 2021 Feb 9. PMID: 33571512.
CR  - 2. Sakurai Y, Higashiguchi T. Transient hyperphosphatase- mia: Possible association with pediatric acute respiratory infection. Pediatr Investig. 2021 Jun 18;5(2):94-98. doi: 10.1002/ped4.12265. PMID: 34179704; PMCID: PMC8212759.
CR  - 3. Zhan F, Watanabe Y, Shimoda A, Hamada E, Kobayashi Y, Maekawa M. Evaluation of serum bone alkaline phospha- tase activity in patients with liver disease: Comparison between electrophoresis and chemiluminescent enzyme immunoassay. Clin Chim Acta. 2016 Sep 1;460:40-5. doi: 10.1016/j.cca.2016.06.008. Epub 2016 Jun 9. PMID: 27291655.
CR  - 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Iso- enzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child. 1985 Jul;139(7):736-40. doi: 10.1001/archpedi.1985.02140090098042. PMID: 4014098.
CR  - 5. Chu AS, Rothschild JG. Update on Benign Transient Hyperphosphatasemia: Recognizing an Underappreciated Condition. Clin Pediatr (Phila). 2016 Jun;55(6):564-6. doi: 10.1177/0009922815593908. Epub 2015 Jul 7. PMID: 26156974.
CR  - 6. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr. 2013 Aug;57(2):167-71. doi: 10.1097/MPG.0b013e3182922807. PMID: 23539049.
CR  - 7. Shkalim Zemer V , Hoshen M, Levinsky Y , Richenberg Y , Yosef N, Oberman B, et al. Benign transient hyperphospha- tasemia in infants and children: a retrospective database study. Eur J Pediatr. 2023 Jul;182(7):3211-3216. doi: 10.1007/s00431-023-04995-1. Epub 2023 May 2. PMID: 37127797; PMCID: PMC10151212.
CR  - 8. Erat T, Atar M, Kontbay T. Transient benign hyperp- hosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab. 2020 Dec 14;34(3):385-387. doi: 10.1515/jpem-2020-0503. PMID: 33577728.
CR  - 9. Akcaboy M, Zorlu P, Acoglu EA, Acar M, Oguz MM, Senel S. Human Bocavirus Infection Associated Transient Benign Hyperphosphatasemia in an Infant. Indian J Pediatr. 2016 Aug;83(8):902-3. doi: 10.1007/s12098-016-2156-5. Epub 2016 Jun 1. PMID: 27246826.
CR  - 10. Tchidjou HK, Caron F, Ferec A, Braun K, Hery L, Cas- telain S, et al. Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children. Blood Coagul Fibrinolysis. 2020 Dec;31(8):575-577. doi: 10.1097/MBC.0000000000000954. PMID: 32897891.
CR  - 11. Rasheed E, Mayne P. Transient Hyperphosphatasaemia of Infancy: An Often Unrecognised and Thus Over- Investigated Condition. Ir Med J. 2016 Apr 11;109(4):392.
UR  - https://doi.org/10.55665/troiamedj.1767889
L1  - https://dergipark.org.tr/en/download/article-file/5166464
ER  -