TY  - JOUR
T1  - Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats
AU  - Kandemir, Fatih Mehmet
AU  - Şimşek, Hasan
PY  - 2025
DA  - September
Y2  - 2025
JF  - Anatolian Journal of Medical Sciences
PB  - Bilecik Seyh Edebali University
WT  - DergiPark
SN  - 3108-4915
SP  - 29
EP  - 35
VL  - 1
IS  - 1
LA  - en
AB  - Introduction: This study aimed to determine the protective effect of Rutin on Colistin-induced sciatic nerve injury.Methods: Thirty-five rats were divided into five groups: control, Rutin, Colistin, Colistin+Rutin50, and Colistin+Rutin100. Biochemically, malondialdehyde (MDA), glial fibrillary acidic protein (GFAP), nerve cell adhesion molecule (NCAM), nuclear factor kappa B (NF-κB), cyclooxygenase 2 (COX-2), and neuronal nitric oxide synthase (nNOS), and parameters were analyzed.Results: Colistin treatment caused sciatic nerve injury by increasing MDA levels (p  < 0.05) leading to lipid peroxidation; by increasing COX-2, NF-κB, and nNOS levels (p  < 0.05) leading to inflammation; and by increasing GFAP levels and decreasing NCAM levels (p  < 0.05). Colistin+Rutin50 and Colistin+Rutin100 treatments were found to have therapeutic effects against sciatic nerve injury by decreasing MDA levels and lipid peroxidation, decreasing NF-κB, COX-2, and nNOS levels and inflammation, decreasing GFAP levels, and increasing NCAM levels.Conclusion: Overall, Rutin was found to have a therapeutic effect against Colistin-induced sciatic nerve injury.
KW  - Colistin
KW  - Rutin
KW  - Inflammation
KW  - GFAP
KW  - NCAM
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UR  - https://dergipark.org.tr/en/pub/ajms/issue//1773084
L1  - https://dergipark.org.tr/en/download/article-file/5190836
ER  -