@article{article_1773774, title={Inflammatory indices in hypertensive hemodialysis patients: clinical implications of MPV and MPVLR}, journal={Journal of Medicine and Palliative Care}, volume={6}, pages={569–574}, year={2025}, DOI={10.47582/jompac.1773774}, author={Bulut Arıkan, Funda and Öztürk, Hakkı}, keywords={Hypertension, hemodialysis, immune-inflammatory indices, hematological markers, biochemical marker}, abstract={Aims: Hemodialysis is marked by persistent activation of inflammatory pathways, leading to immune dysregulation and increased cardiovascular morbidity and mortality. Hypertension is highly prevalent among these patients, with growing evidence implicating systemic inflammation and immune mechanisms in its development. This study aimed to evaluate the influence of hypertension on systemic inflammatory and immune-inflammatory indices, as well as hematological and biochemical parameters, in hemodialysis. Methods: This retrospective multicenter study was conducted with 223 patients receiving hemodialysis. Patients were divided into hypertensive (n=90) and normotensive (n=133) groups. Systemic immune-inflammatory indices, including SII, SIRI, PIV, NLR, LMR, PLR, and MPVLR, were calculated. Hematological and biochemical parameters were comprehensively analyzed. Diagnostic performance of biomarkers was assessed using receiver operating characteristic (ROC) curve analysis. Results: Hypertensive hemodialysis patients showed significantly higher MPVLR (p=0.033) and MPV (p=0.039), along with reduced lymphocyte counts (p=0.002), hematocrit (p=0.021), and serum calcium levels (p=0.021) compared with normotensive patients. In sex-stratified analyses, females had higher SII, PIV, MPVLR, and lipid levels, while sodium and ALT were lower than in males (all p <0.05). ROC analysis demonstrated high specificity for MPV (83.0%) and high sensitivity for MPVLR (78.9%) in distinguishing hypertensive status. Correlation analysis revealed MPVLR was positively associated with MPV, NLR, and PLR, while SII strongly correlated with multiple inflammatory markers. Conclusion: Hypertension in hemodialysis patients is implicated in elevated MPV and MPVLR, along with reduced lymphocyte counts, hematocrit, and calcium levels, which may indicate platelet activation, immune dysregulation, and metabolic imbalance. These parameters may provide adjunctive and cost-effective information for risk stratification and the follow-up of systemic inflammation in this vulnerable patient group. Importantly, sex based variations highlight the importance of personalized treatment approaches.}, number={5}, publisher={MediHealth Academy Yayıncılık}