TY  - JOUR
T1  - A Closer Look at Magnesium Supplementation in Normomagnesemic Patients: Does Formulation Make a Difference?
TT  - Normomagnezemik Hastalarda Magnezyum Takviyesine Daha Yakından Bakış: Formülasyon Fark Yaratır mı?
AU  - Çetinarslan, Özge
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.53446/actamednicomedia.1774901
JF  - Acta Medica Nicomedia
JO  - Acta Med Nicomedia
PB  - Kocaeli University
WT  - DergiPark
SN  - 2717-8994
SP  - 379
EP  - 387
VL  - 8
IS  - 3
LA  - en
AB  - Objectives: Magnesium (Mg) influences vascular tone, cardiac conduction, and autonomic balance. Its use as an oral supplement has increased rapidly in recent years. However, comparative data on oral formulations are limited, particularly in individuals with normal serum Mg levels. This study aimed to compare the haemodynamic, electrophysiologic, and autonomic effects of Mg oxide with an organic combination (malate + bisglycinate + citrate) in normomagnesemic adults.Methods: We conducted a single‑centre, ambispective cohort of 181 adults assigned to Mg‑oxide (n=62),combination (n=61), or control (no supplement; n=58). All participants had paired evaluations after ≥1month including ECG, 24‑hour Holter, and ambulatory blood pressure monitoring (ABPM). Outcomes were24‑hour BP and HR, ECG intervals, arrhythmic burden, and time‑ and frequency‑domain HRV. Adjustedanalyses used inverse‑probability weighting. Key exclusions were recent medication changes, cardiacimplantable devices, chronic kidney disease, new cardiovascular disease, active infection, and shifts inphysical activity.Results: Serum Mg increased in both supplementation arms; serum creatinine fell modestly, with nobetween‑group differences in change. Compared with combination and control, Mg‑oxide achieved greaterreductions in 24‑hour systolic BP (mean Δ −4.2 mmHg; p=0.003) and 24‑hour diastolic BP (Δ −3.5 mmHg;p=0.003), plus a decrease in nighttime diastolic BP (Δ −4.4 mmHg; p=0.014). HR also declined with Mg‑oxideovernight (Δ −2.9 bpm; p=0.049) and over 24 hours (Δ −2.9 bpm; p=0.007), whereas changes with thecombination or control were negligible. Time‑domain HRV improved with Mg‑oxide (RMSSD +22.2 ms,p=0.000; pNN50 +2.9%, p=0.006; NN50 +4.1×10³, p=0.032), with between‑group differences favouringMg‑oxide for RMSSD, pNN50, and NN50 (all p
KW  - Autonomic modulation
KW  - Heart rate variability
KW  - Magnesium oxide
KW  - Magnesium supplementation
KW  - Organic magnesium
KW  - Sleep satisfaction
N2  - Amaç: Magnezyum (Mg) damar tonusu, kardiyak ileti ve otonom dengeyi etkiler. Oral takviye olarak kullanımı son zamanlarda hızla artmaktadır. Ancak özellikle normal serum Mg düzeylerine sahip bireylerde, oral formlara ilişkin karşılaştırmalı veriler sınırlıdır. Bu çalışma, normomagnezemik erişkinlerde Mg oksitin organik bir kombinasyonla (malat + bisglisinat + sitrat) karşılaştırıldığında hemodinamik, elektrofizyolojik ve otonom etkilerini karşılaştırmayı amaçladı.Yöntem: Tek merkezli, ambispektif bir kohort içinde 181 erişkin Mg‑oksit (n=62), kombinasyon (n=61) veya kontrol (takviye yok; n=58) gruplarına ayrıldı. Tüm katılımcılarda ≥1 ay sonra eşleşik değerlendirmeler yapıldı; elektrokardiyografi (EKG), 24 saatlik holter ve ambulatuvar kan basıncı izlemi (ABPM) tekrarlandı. Sonuçlar 24 saatlik kan basıncı ve kalp hızı, EKG aralıkları, aritmik yük ve zaman ile frekans alanı kalp hızı değişkenliği (HRV) parametreleriydi. Temel dışlama kriterleri yakın zamanda ilaç değişikliği, kardiyak implante edilebilir cihazlar, kronik böbrek hastalığı, yeni kardiyovasküler hastalık, aktif enfeksiyon ve fiziksel aktivitede değişimdi.Bulgular: Her iki takviye kolunda serum Mg arttı; serum kreatinin mütevazı ölçüde azaldı ve değişimde grup‑arası fark yoktu. Kombinasyon ve kontrole kıyasla Mg‑oksit, 24 saatlik sistolik kan basıncında(ortalama Δ −4.2 mmHg; p=0.003) ve 24 saatlik diyastolik kan basıncında(Δ −3.5 mmHg; p=0.003) daha büyük düşüşler sağladı; ayrıca gece diyastolik kan basıncında azalma (Δ −4.4 mmHg; p=0.014) görüldü. Kalp hızı, Mg‑oksit ile gece (Δ −2.9 atım/dk; p=0.049) ve 24 saat boyunca (Δ −2.9 atım/dk; p=0.007) azaldı; kombinasyon ve kontrolde değişiklikler ihmal edilebilir düzeydeydi. Zaman alanı HRV, Mg‑oksit ile iyileşti (RMSSD +22.2 ms, p=0.000; pNN50 +2.9%, p=0.006; NN50 +4.1×10³, p=0.032); RMSSD, pNN50 ve NN50 için grup‑arası farklar Mg‑oksit lehineydi (tümü p
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UR  - https://doi.org/10.53446/actamednicomedia.1774901
L1  - https://dergipark.org.tr/en/download/article-file/5199057
ER  -