TY  - JOUR
T1  - Antioxidant, Anticholinesterase and Antiproliferative Properties of the Wild Mushroom Hygrocybe Conica
AU  - Korkmaz, Aras Fahrettin
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.32571/ijct.1779215
JF  - International Journal of Chemistry and Technology
JO  - Int. J. Chem. Technol.
PB  - Rabia ACEMİOĞLU
WT  - DergiPark
SN  - 2602-277X
SP  - 280
EP  - 286
VL  - 9
IS  - 2
LA  - en
AB  - In this study, antioxidant, anticholinesterase and antiproliferative properties of ethanol extracts of Hygrocybe conica were determined. The ethanol extract of the mushroom was extracted by Soxhlet apparatus. Antioxidant activities were determined by TAS, TOS, OSI, DPPH and FRAP analyses. The TAS value of the mushroom extract was 3.559 mmol/L, TOS value was 9.350 µmol/L and OSI value was 0.263. Radical scavenging and reducing capacities were also notable, with DPPH measured as 52.360 mg TE/g and FRAP as 78.503 mg TE/g. Anticholinesterase assays revealed moderate enzyme inhibition with IC₅₀ values of 169.29 µg/mL for AChE and 213.41 µg/mL for BChE, indicating lower activity compared to galantamine. The antiproliferative effect was evaluated in the A549 lung cancer cell line, where the extract significantly reduced cell viability in a dose-dependent manner, with the most pronounced inhibition observed at 200 µg/mL. These findings suggest that H. conica is a promising natural source of bioactive compounds with antioxidant, neuroprotective, and anticancer potential.
KW  - Hygrocybe conica
KW  - antioxidant activity
KW  - anticholinesterase
KW  - antiproliferative effect
KW  - bioactive compounds
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UR  - https://doi.org/10.32571/ijct.1779215
L1  - https://dergipark.org.tr/en/download/article-file/5219370
ER  -