TY - JOUR T1 - Evaluation of the risk of venous thromboembolism in patients with bullous pemphigoid: a single-centre retrospective cohort study TT - Büllöz pemfigoid hastalarında venöz tromboemboli riskinin değerlendirilmesi: tek merkezli retrospektif kohort çalışma AU - Ertop Doğan, Pelin AU - Hazinedar, Emel AU - Köktürk, Fürüzan AU - Ertop, Şehmus PY - 2025 DA - September Y2 - 2025 DO - 10.5798/dicletip.1785022 JF - Dicle Medical Journal JO - diclemedj PB - Dicle University WT - DergiPark SN - 1300-2945 SP - 517 EP - 523 VL - 52 IS - 3 LA - en AB - Objective: Bullous pemphigoid (BP) is an autoimmune blistering disease that predominantly affects elderly individuals. It has been associated with various comorbidities, including neuropsychiatric disorders and diabetes mellitus. In patients with BP, elevated levels of prothrombin and D-dimer, as well as increased tissue factor expression, have been frequently observed, which may lead to endothelial activation. Its pathophysiology and predilection for older age may contribute to an increased risk of venous thromboembolism (VTE). Therefore, in this study, we aimed to retrospectively investigate the clinical characteristics, survival, frequency of VTE, and its impact on survival in patients diagnosed with BP.Methods: In this study, the clinical characteristics, survival duration, VTE incidence, and its impact on survival were retrospectively evaluated in patients who presented to Zonguldak Bülent Ecevit University between 2010-2024 and had a clinical and histopathological diagnosis of BP.Results: A total of 53 patients (37 female, 16 male) were included in the study. The mean age at diagnosis was 75.15 years (± 9.7). The most common comorbidities were diabetes mellitus (n=35) and hypertension (n=30). The median survival time was estimated at 39 months according to survival analysis. VTE was observed in 3 patients (5.7%). The incidence rate of VTE in BP patients was 42.6 per 1,000 person-years. The incidence rate of VTE in BP was found to be statistically significantly higher compared with the incidence rate of VTE in the population over 18 years of age and in the elderly population in population-based studies (p KW - bullous pemphigoid KW - venous thromboembolism KW - survival N2 - Amaç: Büllöz pemfigoid (BP), genellikle yaşlı bireylerde görülen otoimmün büllöz bir hastalıktır. Nöropsikiyatrik hastalıklar, diyabetes mellitus gibi birçok hastalık ile ilişkilendirilmektedir. BP hastalarında sıklıkla endotel aktivasyonuna yol açabilecek artmış protrombin ve D-dimer yüksekliği ile artmış doku faktörü ekspresyonunun olduğu gösterilmiştir. Patofizyolojisi ve ileri yaşta görülmesi venöz tromboemboli (VTE) riskini arttırabilmektedir. Bu nedenle çalışmamızda BP tanısı almış hastaların klinik özelliklerini, sağkalım sürelerini, VTE sıklığını ve bunun sağkalıma etkisini retrospektif olarak incelemeyi planladık.Yöntemler: Bu çalışmada Zonguldak Bülent Ecevit Üniversitesi’ne 2010-2024 yılları arasında başvurmuş klinik ve histopatolojik olarak BP tanısı almış hastaların klinik özellikleri, sağkalım süreleri, VTE sıklığı ve bunun sağkalıma etkisi retrospektif olarak değerlendirildi.Bulgular: Çalışmaya 53 (37 kadın, 16 erkek) hasta dahil edildi. Tanı anında yaş ortalaması 75.15’di(± 9.7). En sık eşlik eden hastalıklar diyabetes mellitus (n=35) ve hipertansiyondu (n=30). Yapılan yaşam analizi sonucunda medyan yaşam süresi 39 ay olarak hesaplandı. VTE, 3 hastada (%5.7) gözlendi. BP hastalarında VTE görülme insidans oranı 1,000 kişi-yıl başına 42.6 olarak hesaplandı. Bu çalışmadaki BP’de VTE insidansı, toplum bazlı çalışmalardaki VTE’nin 18 yaş üzerinde ve yaşlı popülasyonda görülme sıklığı ile karşılaştırıldığında, istatiksel olarak anlamlı derece yüksek bulundu (p CR - 1.Miyamoto D, Santi CG, Aoki V, Maruta CW. Bullouspemphigoid. An Bras Dermatol. 2019;94:133-46. CR - 2.Kilic Sayar S, Sun GP, Kucukoglu R. Comorbiditiesof bullous pemphigoid: A single-center retrospective case-control study from Turkey. Dermatol Ther.2021;34:e15031. CR - 3.Martin E, Mauer I, Malzahn U, et al. Comorbiddiseases among bullous pemphigoid patients inGermany: new insights from a case-control study. JDtsch Dermatol Ges. 2022;20:798-805. CR - 4.Huttelmaier J, Benoit S, Goebeler M. Comorbidityin bullous pemphigoid: up-date and clinicalimplications. Front Immunol. 2023;14:1196999. CR - 5.Brown LF, Harrist TJ, Yeo KT, et al. 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