TY  - JOUR
T1  - Clinicopathological Evaluation of Patients with SMILE, Cervical Intraepithelial Neoplasia 3, and Adenocarcinoma in Situ
TT  - SMILE, Servikal İntraepitelyal Neoplazi 3 ve Adenokarsinoma in situ Hastalarının Klinikopatolojik Değerlendirilmesi
AU  - Sözen, Işık
AU  - Arslan, Hilal Serap
AU  - Şahin, Gözde
AU  - Aboalhasan, Yasemin
AU  - Tasti, Elif Dila
AU  - Temel, İlkbal
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.18663/tjcl.1788113
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 625
EP  - 633
VL  - 16
IS  - 3
LA  - en
AB  - Aim: To compare cervical biopsy diagnoses with final surgical pathology results among patients with SMILE, CIN3, and AIS, and to evaluate differences in clinical-pathological features between these lesions. Methods: We performed a retrospective single-center analysis of patients diagnosed with SMILE (n=8), CIN3 (n=16), or AIS (n=14) who underwent surgical treatment. Clinical variables, high-risk HPV genotypes, cervical cytology findings, treatment modality, and pathological outcomes of surgical specimens were reviewed.Results: The distribution of HPV high-risk genotypes and cytologic diagnoses were similar between the groups (p>0.05). The rate of hysterectomy performed during initial treatment or after reoperation was higher in patients with AIS compared to the other groups. The concordance between the preliminary biopsy diagnosis and the pathological diagnosis after surgical excision differed significantly across lesion types (p
KW  - Cervical cytology
KW  - colposcopy
KW  - biopsy
KW  - concordance
KW  - cervical intraepithelial neoplasia
KW  - Adenocarcinoma in situ
KW  - SMILE
N2  - Amaç: SMILE, CIN3 ve AIS tanılı hastalarda servikal biyopsi sonuçlarının konizasyon/histerektomi sonrası kesin patolojik tanılarla uyumunu ve klinik özelliklerdeki farklılıkları karşılaştırmak.Yöntemler: Tek merkezli retrospektif bir çalışma kapsamında SMILE (n=8), CIN3 (n=16) veya AIS (n=14) tanısı alarak cerrahi tedavi uygulanmış hastaların klinikopatolojik verileri incelenmiştir. Hastaların HPV genotip sonuçları, sitoloji (Pap smear) bulguları, uygulanan cerrahi işlemler ve cerrahi örneklerin patoloji sonuçları retrospektif olarak kayıt edildi.Bulgular: HPV yüksek riskli genotip dağılımı ve sitolojik tanılar gruplar arasında benzer bulundu (p>0.05). AIS tanılı hastalarda ilk tedavide veya yeniden cerrahi sonrası histerektomi uygulanma oranı diğer gruplara kıyasla daha yüksekti. Biyopsi ön tanısı ile cerrahi eksizyon sonrası patoloji tanısının uyumu lezyon tiplerine göre anlamlı farklılık gösterdi (p
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UR  - https://doi.org/10.18663/tjcl.1788113
L1  - https://dergipark.org.tr/en/download/article-file/5260371
ER  -