@article{article_1790185, title={Determination of Accumulation, Elimination Amounts and Some Biomarker Responses of Chlorpyrifos Pesticide in Navicula cryptocephala}, journal={The Trout Journal of Atatürk University}, volume={3}, pages={29–38}, year={2025}, DOI={10.62425/tjau.1790185}, author={Serdar, Osman and Aydın, Ayşe Nur and Ölçülü, Abdullatif and Çiçek Çimen, Işıl Canan and Parlak Ak, Tuba and Derman, Taner and Pala, Ayşegül and Cikcikoglu Yildirim, Nuran}, keywords={Navicula cryptocephala, Cylorpyrifos, accumilation, biomarker}, abstract={Pesticides such as chlorpyrifos (CPF), which are used to combat pests in agricultural areas, mix with the aquatic environment in various ways and pose a danger to the aquatic environment. In this study, chlorpyrifos was used in Navicula cryptocephala it was aimed to examine the accumulation, elimination amounts and some biomarker responses. EC50 values were determined as 0.19 mg/L and acute toxicity values were realized at 1/8, 1/4 and 1/2 of EC50 values. Model organisms were exposed to CPF for 24, 48, 72, 96 and 120 days (elimination period). Accumulation amounts from the samples taken at 24 and 96 hours were measured using Atomic Absorption Spectophotometry (AAS) mass spectrometry. With the supernatants obtained, lipid peroxidation (TBARS) and reduced glutathione (GSH) levels, superoxide dismutase (SOD) enzyme activity, glutathione peroxidase (GPx) enzyme activity, catalase (CAT) enzyme activity were determined with an ELISA microplate reader. According to research data, it was determined that the bioaccumulation amount of the CPF active ingredient in microalgae increased as the application concentration and duration increased. It was determined that the biomarker parameters showed statistically significant changes in the control and elimination groups compared to the application groups.}, number={2}, publisher={Ataturk University}, organization={TÜBİTAK}