TY  - JOUR
T1  - Terpenes in Mushrooms: Natural Products with Diverse Therapeutic Activities
AU  - Şöhretoğlu, Didem
AU  - Avcı, Eda
AU  - Kuruüzüm-uz, Ayşe
PY  - 2026
DA  - March
Y2  - 2025
DO  - 10.52794/hujpharm.1790368
JF  - Hacettepe University Journal of the Faculty of Pharmacy
JO  - HUJPHARM
PB  - Hacettepe University
WT  - DergiPark
SN  - 2458-8806
SP  - 61
EP  - 71
VL  - 46
IS  - 1
LA  - en
AB  - This study provides a comprehensive review of the terpenes found in mushrooms and their potential therapeutic applications. Mushrooms are rich sources of various terpenes, including monoterpenes, sesquiterpenes, diterpenes, and triterpenes, which possess antibacterial, antiviral, antifungal, antiparasitic, antioxidant, anti-inflammatory, antidiabetic, and cytotoxic activities. Notable examples include pleuromutilin, a precursor of the antibiotic retapamulin; ganoderic acids from Ganoderma lucidum with anti-HIV effects; sesquiterpenes from Albatrellus dispansus that are effective against phytopathogenic fungi; and lanostane triterpenes from G. lucidum and G. leucocontextum with neuroprotective effects. The present findings highlight the therapeutic potential of mushroom terpenes. However, the authors underscore the necessity for further in vitro studies to elucidate the mechanisms of action, along with in vivo studies, toxicity investigations, and clinical trials.
KW  - Bioactive compounds
KW  - Mushrooms
KW  - Natural products
KW  - Terpenes
KW  - Therapeutic applications
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