TY - JOUR T1 - Synthesis of various DNA hybrid nanocomposites and investigation of peroxidase mimic activity TT - Çeşitli DNA hibrit nanokompozitlerin sentezlenmesi ve enzimatik aktivitenin incelenmesi AU - Çelik Yoldaş, Çağla AU - Demir, Ali AU - Nacar, Asena Elif AU - Öçsoy, İsmail PY - 2026 DA - February Y2 - 2025 DO - 10.46309/biodicon.2026.1794117 JF - Biological Diversity and Conservation JO - BioDiCon PB - Ersin YÜCEL WT - DergiPark SN - 1308-5301 SP - 1 EP - 9 VL - 19 IS - 1 LA - en AB - AbstractPurpose: The aim of this study is to synthesize hybrid nanocomposites from various DNA sequences and to investigate their peroxidase mimic activities.Method: The DNA sequences were used as the organic component and the copper (II) ions were used as the inorganic component for the synthesis. The effect of different synthesis conditions (pH and concentration) on morphology was investigated using a scanning electron microscope. Additionally, the peroxidase mimic activity of nanocomposites was examined.Findings: DNA sequences coded as C20, C20A and C20AA were used at various concentrations within three synthesis environments with different pH levels. This resulted in the formation of flower-like hybrid nanocomposite structures. These structures also exhibited effective peroxidase mimic activity.Conclusion: Various DNA hybrid nanocomposites can be synthesised successfully. These nanocomposites could be used in DNA-related drug delivery systems. KW - DNA KW - nanocomposite KW - peroxidase mimic activity N2 - ÖzetAmaç: Bu çalışmanın amacı çeşitli DNA sekanslarından hibrit nanokompozitler sentezlenmesi ve peroksidaz benzeri aktivitelerinin araştırılmasıdır.Metod: Sentez için organik kısım olarak DNA sekansları, inorganik kısım olarak bakır (II) iyonları kullanılmıştır. Taramalı elektron mikroskobu ile farklı sentez şartlarının (pH, konsantrasyon) morfolojiye olan etkisi incelenmiştir. Ayrıca nanokompozitlerin peroksidaz benzeri aktivitesi araştırılmıştır.Bulgular: C20, C20A ve C20AA kodlu DNA sekansları farklı konsantrasyonlarda kullanılarak farklı pH değerine sahip üç farklı sentez ortamında istenilen çiçek benzeri hibrit nanokompozit yapılar oluşmuştur. Bu yapılar etkili peroksidaz enzim benzeri aktivite de sergilemişlerdir.Sonuç: Çeşitli DNA sekanslarından DNA hibrit nanokompozitler başarıyla sentezlenebilmektedir. Bu nanokompozitler DNA ilişkili ilaç taşıyıcı sistemlerde kullanılabilme potansiyeli taşımaktadır. CR - [1] Camargo, P. H. C., Satyanarayana, K. G. & Wypych, F. (2009). Nanocomposites: synthesis, structure, properties and new application opportunities. Materials Research, 12(1), 1–39. https://doi.org/10.1590/S1516-14392009000100002 CR - [2] Loy, D. A. & Shea, K. J. (1995). Bridged polysilsesquioxanes: Highly porous hybrid organic-inorganic materials. Chemical Reviews, 95(5), 1431–1442. https://doi.org/10.1021/cr00037a013 CR - [3] Díaz, U. & Corma, A. 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