TY  - JOUR
T1  - Capparis spinosa aerial parts total extract and ethyl acetate partition showed promising antidepressant effects in mice model
AU  - Mesripour, Azadeh
AU  - Khayambashi, Mohamad Farid
AU  - Sadeghi Dinani, Masoud
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.12991/jrespharm.1797830
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 2327
EP  - 2335
VL  - 29
IS  - 6
LA  - en
AB  - Capparis spinosa, displays protection against oxidative stress, neuroinflammation, and neurodegenerative disorders. Considering the beneficial effects of C. spinosa since its antidepressant effects have not been studied before, we investigated antidepressant efficacy of the total extract (TCS) and ethyl acetate extract (ECS) of C. spinosa in mice. Male mice (27±2 g) were used. To initiate depression, dexamethasone (Dex, 15 μg/kg subcutaneously) was injected for two weeks, ECS or TCS were administered by gavage feeding tube daily. After the locomotor test, depression criteria were evaluated by forced swim test (FST), sucrose preference (SP) test, and novelty-suppressed feeding test (NSFT). Dex increased immobility time during FST, latency to food intake increased during NSFT compared to normal group, and SP reduced. TCS or ECS (50-25 mg/kg) each alone reduced immobility time during FST (versus control, p  < 0.01), and elevated SP to above 65% proved to have antidepressant effect. After the combination treatment Dex-TCS and Dex-ECS a notable reduction in immobility time was seen in FST (versus Dex alone group, p  < 0.001). During NSFT in Dex-TCS and Dex-ECS the latency time significantly reduced (p  < 0.05 versus Dex). These results were comparable with fluoxetine coadministration. The changes in locomotor activity did not interfere with the FST results. ECS and TCS exhibited antidepressant-like effects in mice, that is potentially related to a mixture of effects including antioxidant and neuroprotective properties that warrant further investigation.
KW  - Capparis spinosa
KW  - depression
KW  - mice
KW  - animal model
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UR  - https://doi.org/10.12991/jrespharm.1797830
L1  - https://dergipark.org.tr/en/download/article-file/5304610
ER  -