TY  - JOUR
T1  - Chromium picolinate enhances reproductive success and development in Drosophila melanogaster by reducing oxidative stress
AU  - B. Dhadde, Shivsharan
AU  - S. Kalshetti, Mallinath
PY  - 2025
DA  - November
Y2  - 2024
DO  - 10.12991/jrespharm.1798361
JF  - Journal of Research in Pharmacy
JO  - J. Res. Pharm.
PB  - Marmara University
WT  - DergiPark
SN  - 2630-6344
SP  - 2565
EP  - 2573
VL  - 29
IS  - 6
LA  - en
AB  - Chromium picolinate (Cr(Pico)₃) is widely recognized for its ability to enhance insulin sensitivity.However, its broader effects, particularly on reproductive and developmental parameters, have not been extensivelyexplored. The present study evaluated the impact of Cr(Pico)₃ supplementation on reproductive physiology anddevelopmental outcomes in Drosophila melanogaster, with an emphasis on oxidative stress modulation. The studyinvolved treating Drosophila melanogaster with four doses of Cr(Pico)₃ (5, 10, 15, and 20 µg/ml of diet) and monitoringkey reproductive and developmental parameters, such as larval and pupal periods, pupation rates, adult fly emergence,and egg hatching. The results demonstrated that supplementation with Cr(Pico)₃ at 15 µg/ml significantly shortenedlarval and pupal periods by 8.0% and 6.4%, respectively (p  < 0.001), and improved the percentage of pupae and adultfly emergence by 7.8% and 7.4%, respectively. Additionally, Cr(Pico)₃ enhanced fecundity by 13.9% and fertility by13.6% at 15 µg/ml, compared to the control group. Antioxidant enzyme activities, including catalase (CAT), superoxidedismutase (SOD), and glutathione-S-transferase (GST), were also significantly elevated in Cr(Pico)₃-treated flies (p  <0.05), suggesting a strong defence against oxidative stress. These results indicate that Cr(Pico)₃ can enhancereproductive success and developmental efficiency by promoting antioxidant defence mechanisms. Further studies arewarranted to explore the potential of Cr(Pico)₃ in other model organisms, with broader implications for its use inaddressing human oxidative stress-related reproductive dysfunction.
KW  - Chromium picolinate
KW  - Dietary supplement
KW  - oxidative stress
KW  - fertility
KW  - fecundity
KW  - antioxidant enzymes
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UR  - https://doi.org/10.12991/jrespharm.1798361
L1  - https://dergipark.org.tr/en/download/article-file/5307065
ER  -