TY  - JOUR
T1  - Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004 Study
AU  - Atasoy, Beste
AU  - Özkurt, Selnur
AU  - Doğan, Bedriye
AU  - Özyılmaz, Nagehan
AU  - Aykaç, Aslı
AU  - Ertaş, Büşra
AU  - Şen, Ali
AU  - Ceylan, Cemile
AU  - Ercan, Feriha
PY  - 2025
DA  - October
Y2  - 2025
JF  - Marmara Medical Journal
JO  - Marmara Med J
PB  - Marmara University
WT  - DergiPark
SN  - 1019-1941
SP  - 190
EP  - 197
VL  - 38
IS  - 3
LA  - en
AB  - Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samplesin an animal model.Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF)for four days. Ionizing radiation (IR) groups were organized as follows: “IR group (IR)” (n=8) received oral SF for four days starting onthe day of administration; “MC treatment group (MC-tx)” (n=8) received oral MC for four days beginning on the day of irradiation;and “MC pretreatment group (MC-Ptx)” (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC wasadministered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats weresacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting toassess mitochondrial apoptosis.Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower inthe MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01).Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic andtherapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.
KW  - Bladder
KW  - Kidney
KW  - Myrtus communis
KW  - Radioprotection
KW  - Rats
KW  - Ovary
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UR  - https://dergipark.org.tr/en/pub/marumj/issue//1798589
L1  - https://dergipark.org.tr/en/download/article-file/5308042
ER  -