TY  - JOUR
T1  - Investigation of Anticancer Activity of Ochratoxin Against Prostate Cancer Cell Line
AU  - Başak Türkmen, Neşe
AU  - Küçük, İrem Sena
AU  - Icen Taskın, Irmak
AU  - Yaşar, Şeyma
AU  - Aşkın Özek, Dilan
AU  - Yüce, Hande
Y2  - 2025
DO  - 10.71133/anatphar.1800039
JF  - Anatolian Journal of Pharmaceutical Sciences
JO  - AJPS
PB  - Inonu University
WT  - DergiPark
SN  - 2980-0463
SP  - 142
EP  - 149
VL  - 4
IS  - 3
LA  - en
AB  - Prostate cancer is one of the most prevalent malignancies among men and remains a significant public health concern due to its high mortality rate, despite the availability of current treatment strategies. Ochratoxin, a naturally occurring mycotoxin, has attracted considerable attention for its diverse biological activities. This study explores the anticancer potential of ochratoxin in prostate cancer cell lines. Cell viability was evaluated following treatment with defined concentrations of ochratoxin, and apoptotic mechanisms, along with gene expression profiles, were analyzed. The results demonstrate that ochratoxin suppresses cell proliferation and induces apoptosis in a dose-dependent manner. These findings suggest that ochratoxin may represent a promising candidate for prostate cancer therapy. However, further in vivo studies are necessary to confirm its clinical relevance and therapeutic applicability.
KW  - Prostate cancer
KW  - Ochratoxin
KW  - Anticancer activity
KW  - Apoptosis
KW  - Cell proliferation
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[11]  Migliaccio G, Ferraro R, Wang Z, Cristini V, Dogra P, Caserta S. Exploring Cell Migration Mechanisms in Cancer: From Wound Healing
UR  - https://doi.org/10.71133/anatphar.1800039
L1  - https://dergipark.org.tr/en/download/article-file/5314617
ER  -