TY  - JOUR
T1  - Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge
AU  - Chauhan, Kavita
AU  - Singal, Kabir
AU  - Syed, Asmara
AU  - Agarwal, Anshoo
AU  - Hussain, Syed Sajid
AU  - Subramaniam, S. Geetha
AU  - Elmorsy, Ekramy M.
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.5472/marumj.1800775
JF  - Marmara Medical Journal
JO  - Marmara Med J
PB  - Marmara University
WT  - DergiPark
SN  - 1019-1941
SP  - 278
EP  - 282
VL  - 38
IS  - 3
LA  - en
AB  - One of the more aggressive cancers that has the potential to spread to other body parts is renal cell carcinoma (RCC). The mostfrequent sites of metastasis are the lungs, liver, and bones. Reports of RCC spreading to the skin, especially the scalp, are uncommon.While RCC metastases to the scalp are rare, they should be taken into account because of their poor prognosis and great potentialfor spreading, thereby reducing life expectancy in humans. Here, we report a patient who was diagnosed with RCC and also had ametastatic scalp lesion.
KW  - Renal cell carcinoma
KW  - Metastasis
KW  - Skin neoplasms
KW  - Scalp lesions
KW  - Head and neck tumors
KW  - Osteolytic lesions
CR  - Errami M, Margulis V, Huerta S. Renal cell carcinoma
metastatic to the scalp. Rare Tumors 2016;8:139-41. doi:
10.4081/rt.2016.6400
CR  - Dashow JE, Gemmete JJ, McHugh JB, Helman J. Metastatic
clear cell renal carcinoma of the palate mimicking
noninvoluting congenital hemangioma, J Oral Mazillofac Surg
2011;69:1836-41. doi: 10.1016/j.joms.2010.07.050
CR  - Amaadour L, Atreche L, Azegrar M, et al. Cutaneous
metastasis of renal cell carcinoma: a case report. J Cancer Ther
2017;8:603-7. doi: 10.4236/jct.2017.86051
CR  - Byun SS, Hong SK, Lee S, et al. The establishment of KORCC
(KOrean Renal Cell Carcinoma) da tabase. Investig Clin Urol
2016;57:50-7. doi: 10.4111/icu.2016.57.1.50
CR  - de Paula TA, da Silva PS, Berriel LG. Renal cell carcinoma with
cutaneous metastasis: case report. J Bras Nefrol 2010;32:213-5.
doi: 10.1590/S0101.280.0201000.020.0010
CR  - Yeh HC, Yang S-F, Ke H L, Lee KS, Huang C H, Wu W. Renal
cell carcinoma presenting with skull metastasis: a case report
and literature review. Kaohsiung J Med Sci 2007;23: 475-79.
doi: 10.1016/S1607-551X(08)70056-1.
CR  - Huang HC, Chang KP, Chen TM, Wu KF, Ueng SH. Renal cell
carcinoma metastases in the head and neck. Chang Gung Med
J 2006;29:59-65.
CR  - Snow S, Madjar D, Reizner G, MacK E, Bentz M. Renal cell
carcinoma metastatic to the scalp: case report and review of the
literature. Dermatol Surg 2001;27:192-4. doi: 10.1046/j.1524-
4725.2001.00115.x
CR  - Ishak A I, Pauzi S H, Masir N, Goh B. Multiple metastatic
deposits in the head and neck region from a renal cell
carcinoma. Malay J Med Sci 2010;17:71-4.
CR  - Anzalone CL, Cohen PR, Migden MR, Tannir NM. Mohs
surgery in metastatic cancer: renal cell carcinoma solitary
cutaneous metastasis and visceral tumor metastases to skin
treated with microscopically controlled surgical excision. Int
J Dermatol 2013;52:856-61. doi: 10.1111/ijd.12021
CR  - Pan D, Niall O, Sharma H, Gya D. Isolated scalp nodule in
patient with undiagnosed RCC. ScientificWorldJournal
2006;6: 2430-2. doi: 10.1100/tsw.2007.377
CR  - Livingston WD Jr, Becker DW Jr, Lentz CW 3rd. Solitary scalp
metastasis as the presenting feature of a renal carcinoma. Br J
Plast Surg 1977;30:319-20. doi: 10.1016/0007-1226(77)90130-8
CR  - Escudier B, Eisen T, Porta C, et al. Renal cell carcinoma:
ESMO clinical practice guidelines for di agnosis, treatment
and follow-up. Ann Oncol 2012;23 Suppl 7: vii65-71. doi:
10.1093/annonc/mds227
CR  - Gong J, Maia MC, Dizman N, Govindarajan A, Pal SK.
Metastasis in renal cell carcinoma: biology and implications
for therapy. Asian J Urol 2016;3:286-92. doi: 10.1016/j.
ajur.2016.08.006.
CR  - Shuch B, La Rochelle JC, Klatte T, et al. Brain metastasis from
renal cell carcinoma: presenta tion, recurrence, and survival.
Cancer 2008;113:1641-8. doi: 10.1002/cncr.23769
CR  - Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus
in advanced renal cell carcinoma: a double-blind, randomised,
placebo-controlled phase III trial. Lancet 2008;372:449-56.
doi: 10.1016/S0140-6736(08)61039-9
CR  - Meshikhes HA, Al Khatem RS, Albusaleh HM, Alzahir AA.
Metastatic renal cell carcinoma to the scalp: a case report
with review of literature. Cureus 2023, 15:e34790. 10.7759/
cureus.34790. doi: 10.7759/cureus.34790
CR  - Yang HJ, Kang SY. Cutaneous metastatic renal cell carcinoma
to the scalp . Arch Craniofac Surg 2019, 20:392-6. doi: 10.7181/
acfs.2019.00206
CR  - Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla
RM, Toussaint-Caire S. Scalp metastases of a renal cell
carcinoma. Skinmed 2006, 5:148-50. doi: 10.1111/j.1540-
9740.2006.04563.x
CR  - Leve PP, Felício J, Carneiro R, Zagalo C. Recurrent renal cell
carcinoma presenting as a cutaneous metastasis: a case report
and review of the literature. Urol Ann 2021; 13:174-6. doi:
10.4103/UA.UA_2_20
CR  - Gandla S, Ramaswamy V, Rao V. Metastatic renal cell
carcinoma in the head and neck region . Int J Otorhinolaryngol
– Head Neck Surg 2018; 4:1092. doi: 10.18203/issn.2454-5929.
ijohns20182721
CR  - Kishore M, Chauhan DS, Dogra S. Unusual presentation of
renal cell carcinoma: a rare case report . J Lab Physicians
2018;10:241-4. doi: 10.4103/JLP.JLP_153_17
CR  - Eke N, Eghwrudjakpor P, Echem RC. Renal cell carcinoma
presenting as a scalp swelling . Niger J Med 2003; 12:154-6.
CR  - Smyth LG, Casey RG, Quinlan DM. Renal cell carcinoma
presenting as an ominous metachronous scalp metastasis. Can
Urol Assoc J. 2010, 4:E64-6. doi: 10.5489/cuaj.859
CR  - Abbasi F, Alizadeh M, Noroozinia F, Moradi A: Cutaneous
metastasis of bilateral renal cell carcinoma. J Pak Med Assoc
2013, 63:111-3.
CR  - Selvi F, Faquin WC, Michaelson MD, August M. Three
synchronous atypical metastases of clear cell renal carcinoma
to the maxillary gingiva, scalp and the distal phalanx of the
fifth digit: a case report. J Oral Maxillofac Surg 2016;74:1286.
e1-9. doi: 10.1016/j.joms.2016.01.054
CR  - Ferhatoglu MF, Senol K, Filiz AI. Skin metastasis of renal
cell carcinoma: a case report . Cureus 2018; 10:e3614. doi:
10.7759/cureus.3614
CR  - Krogerus C, Svenning M, Pilt AP, Trøstrup H. Renal cell
carcinoma presenting as a tumor on the scalp: a case report. Int
J Surg Case Rep 2020; 76:56-9. doi:10.1016/j.ijscr.2020.09.122
CR  - Altinkaya A, Yazar S, Karadag EC, Er O. Large solitary scalp
metastasis of renal cell carcinoma: a case report . Niger J Clin
Pract 2021; 24:629-31. doi: 10.4103/njcp.njcp_584_19
CR  - ingla A, Sharma U, Makkar A, et al. Rare metastatic sites of
renal cell carcinoma: a case series . Pan Afr Med J 2022; 42:26.
doi: 10.11604/pamj.2022.42.26.33578
CR  - Singh P, Somani K. Latent distant metastasis of renal cell
carcinoma to skin: a case report . Clin Case Rep 2020;8:1138-
41. doi: 10.1002/ccr3.2844
CR  - Hsieh JJ, Purdue MP, Signoretti S, et al. Renal cell carcinoma.
Nat Rev Dis Primers 2017;3:17009. doi: 10.1038/nrdp.2017.9
CR  - Jindal T, Sinha RK, Mukherjee S, Karmakar D. Calvarial and
cutaneous metastasis as the primary presentation of a renal cell
carcinoma. BMJ Case Rep 2014;2014:2014:bcr201.320.2830.
doi: 10.1136/bcr-2013-202830
CR  - Padala SA, Kallam A. Clear cell renal carcinoma. Treasure
Island, FL; StatPearls Publishing, 2023.
CR  - Choueiri TK, Rini B, Garcia JA, et al. Prognostic factors
associated with long-term survival in previously untreated
metastatic renal cell carcinoma. Ann Oncol 2007 18:249-55.
doi: 10.1093/annonc/mdl371.
CR  - Dowell-Esquivel C, Lee R, DiCaprio III RC, Nouri K. Sebaceous
carcinoma: an updated review of pathogenesis, diagnosis,
and treatment options. Arch Dermatol Res 2023;316:55. doi:
10.1007/s00403.023.02747-7
CR  - Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M,
Barahman M, Mafakher L. Renal cell carcinoma: an overview
of the epidemiology, diagnosis, and treatment. G Ital Nefrol
2022;39:2022.
UR  - https://doi.org/10.5472/marumj.1800775
L1  - https://dergipark.org.tr/en/download/article-file/5317744
ER  -