@article{article_188256, title={Protective effect of erdosteine against naphthalene-induced oxidative stress in rats}, journal={Marmara Pharmaceutical Journal}, volume={14}, pages={67–73}, year={2014}, DOI={10.12991/mpj.94959}, author={Şehirli, Ahmet and Şener, Göksel}, keywords={Naphthalene, erdosteine, lipid peroxidation, glutathione, myeloperoxidase}, abstract={<p>ABSTRACT: In this study the role of free radicals in naphthalene-induced toxicity and the <br />protection by erdosteine are investigated. Female Sprague-Dawley rats were treated with a <br />single oral dose of 1100 mg naphthalene/kg in corn oil. Erdosteine was given 50 mg/kg/day <br />orally for 3 days before naphthalene treatment and rats were decapitated 24 hours after <br />naphthalene administration. Liver and kidney tissue samples were taken for determination <br />of malondialdehyde (MDA), glutathione (GSH), Na+, K+-ATPase and myeloperoxidase <br />(MPO) activities. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood <br />urea nitrogen (BUN) and creatinine levels and lactate dehydrogenase (LDH) activity were <br />measured in the serum samples, while TNF- </p>}, number={2}, publisher={Marmara University}