TY  - JOUR
T1  - Protective effect of erdosteine against naphthalene-induced oxidative stress in rats
AU  - Şehirli, Ahmet
AU  - Şener, Göksel
PY  - 2014
DA  - March
DO  - 10.12991/mpj.94959
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 67
EP  - 73
VL  - 14
IS  - 2
LA  - en
AB  - ABSTRACT: In this study the role of free radicals in naphthalene-induced toxicity and theprotection by erdosteine are investigated. Female Sprague-Dawley rats were treated with asingle oral dose of 1100 mg naphthalene/kg in corn oil. Erdosteine was given 50 mg/kg/dayorally for 3 days before naphthalene treatment and rats were decapitated 24 hours afternaphthalene administration. Liver and kidney tissue samples were taken for determinationof malondialdehyde (MDA), glutathione (GSH), Na+, K+-ATPase and myeloperoxidase(MPO) activities. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), bloodurea nitrogen (BUN) and creatinine levels and lactate dehydrogenase (LDH) activity weremeasured in the serum samples, while TNF-
KW  - Naphthalene
KW  - erdosteine
KW  - lipid peroxidation
KW  - glutathione
KW  - myeloperoxidase
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UR  - https://doi.org/10.12991/mpj.94959
L1  - https://dergipark.org.tr/en/download/article-file/165980
ER  -