@article{article_188258, title={Detection of vitamin B12 levels with the aid of some hematological and biochemical parameters that are more sensitive}, journal={Marmara Pharmaceutical Journal}, volume={14}, pages={125–129}, year={2014}, DOI={10.12991/mpj.97985}, author={Asma, Süheyl and Erdoğan, Ferit and Ünsal, Aydan and Boğa, Can and Özdoğu, Hakan and Gereklioğlu, Çiğdem and Kozanoğlu, İlknur and Maytalman, Erkan}, keywords={ANAHTAR KELİMELER: Vitamin B 12, homosistein,antiparietal antikor}, abstract={<p>ABSTRACT: Vitamin B12 deficiency is a health problem, which is usually seen in elderly patients <br />and results in hematological and neurological disorders. In this study, we aimed to <br />investigate the serum levels of vitamin B12 could represent the real tissue levels with considering <br />some hematological and biochemical parameters. 128 patients whose vitamin B12 <br />levels have been detected to be low and their ages are ranged from 16 to 90, have been investigated. <br />Fifty three of them were females. Complete blood counts, antiparietal antibody <br />(APA), homocysteine levels, peripheral blood smear evaluations and findings of gastroduodenoscopy <br />were assessed. Mean volume of erythrocytes has been found as 107 fl in patient <br />group (group 1), in which vitamin B12 level has been detected lower than 60 pg/mL. The <br />higher homocysteine values in 85% cases, neutrophil hyper-segmentation in 82%, atrophic <br />gastritis in 53 % and APA positivity in 47 % of cases have been detected. The average of age <br />has been detected as 65 in this group. High level of homocysteine has been present in 44 % <br />of cases and MCV has been 91 fl in group 2, in which the vitamin B12 levels are between <br />61–100 pg/ mL. In group ( group 3), in which vitamin levels are between 101 – 140 pg /mL, <br />elevated homocysteine levels in 27 % cases and MCV as 89 fl have been detected. In group <br />4, in which vitamin levels are between 141–178 pg/mL, homocysteine elevation in 16 % of <br />cases and MCV as <br />KEY WORDS: Vitamin B 12, homocysteine, anti parietal antibod </p>}, number={3}, publisher={Marmara University}