@article{article_188287, title={The synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5- one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moiety}, journal={Marmara Pharmaceutical Journal}, volume={16}, pages={222–228}, year={2014}, DOI={10.12991/mpj.61269}, author={Oral, Başak and Rollas, Sevim}, abstract={<p>ABSTRACT: Novel derivatives of substituted hydrazone (2a-e), 2-pyrazoline-5-one (3a-e, 4ae) <br />and 2-isoxazoline-5-one (5a-e) derivatives possessing 1,3,4-thiadiazole moiety were synthesized <br />and evaluated for their antitubercular activity. The highest inhibitions were observed <br />with the synthesized compounds are 87% for 3-methyl-4-[4-(5-cyclohexylamino- <br />1,3,4-thiadiazole-2-yl)phenylhydrazono]-2-isoxazoline-5-one (5b) and 86% for ethyl <br />2-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenylhydrazono]-3-oxobutirate (2b). Compounds <br />2b and 5b could be a good initial point to develop new lead compound. <br />KEY WORDS: 1,3,4-thiadiazole, 2-pyrazolin-5-one, 2-isoxazoline-5-one, hydrazone and <br />antitubercular activity </p>}, number={3}, publisher={Marmara University}