@article{article_188291, title={Synthesis, characterization and antiviral evaluation of 1,3-Thiazolidine-4-one derivatives bearing L-Valine side chain}, journal={Marmara Pharmaceutical Journal}, volume={16}, pages={181–193}, year={2014}, DOI={10.12991/mpj.55146}, author={Tatar, Esra and Küçükgüzel, İlkay and De Clercq, Erik and Krishnan, Ramalingam and Basu, Neerja}, keywords={4-Thiazolidinones, L-valine, anti-HIV activity, anti-HCV activity}, abstract={<p>ABSTRACT: 1,3-Thiazolidine-4-ones have been known to possess anti-HIV and anti-HCV activity <br />as they are, respectively, HIV-1 non-nucleoside reverse transcriptase inhibitors and HCV <br />NS5B RNA-dependent RNA-polymerase inhibitors. Some novel 1-[2-(benzoylamino)- <br />3-methylbutyryl]-4-alkyl/arylalkylthiosemicarbazides, 2-[2-(benzoylamino)-3-methylbutyrylhydrazono]- <br />3-alkyl-/arylalkyl- 5-non substituted/methyl-1,3-thiazolidinones, were synthesized <br />and evaluated for their antiviral activity. Antiviral activity of the synthesized compounds were <br />screened against various types of viruses (Feline Corona Virus (FIPV), Feline Herpes Virus, <br />HSV-1(KOS), HSV-1(TK-KOS ACVr), HSV-2(G), Vaccinia virus, Vesicular stomatitis virus, Varicella- <br />ZosterVirus TK+VZV, Varicella-ZosterVirus TK-VZV, Cytomegalovirus, Respiratory syncytial virus, <br />Coxsackie B4 virus, Parainfluenza-3 virus, Reovirus-1, Sindbis virus and Punta Toro virus) in <br />CRFK, HEL, HeLa and Vero cell cultures. Anti-HIV and cytotoxicity data were also obtained <br />with the compounds using the strains HIV-1 (IIIB) and HIV-2 (ROD) in an MT-4/MTT based assay. <br />None of the tested compounds showed antiviral activity at subtoxic concentrations. For <br />all the synthesized compounds anti-HCV NS5B RdRp activity was not observed at the concentration <br />of 100 μM which was the highest concentration tested. <br />KEYWORDS: 4-Thiazolidinones, L-valine, anti-HIV activity, anti-HCV activity. </p>}, number={3}, publisher={Marmara University}