TY  - JOUR
T1  - Synthesis, characterization and antiviral evaluation of 1,3-Thiazolidine-4-one derivatives bearing L-Valine side chain
TT  - Synthesis, characterization and antiviral  evaluation of 1,3-Thiazolidine-4-one  derivatives bearing L-Valine side chain
AU  - Tatar, Esra
AU  - Küçükgüzel, İlkay
AU  - De Clercq, Erik
AU  - Krishnan, Ramalingam
AU  - Basu, Neerja
PY  - 2014
DA  - March
DO  - 10.12991/mpj.55146
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 181
EP  - 193
VL  - 16
IS  - 3
LA  - en
AB  - ABSTRACT: 1,3-Thiazolidine-4-ones have been known to possess anti-HIV and anti-HCV activityas they are, respectively, HIV-1 non-nucleoside reverse transcriptase inhibitors and HCVNS5B RNA-dependent RNA-polymerase inhibitors. Some novel 1-[2-(benzoylamino)-3-methylbutyryl]-4-alkyl/arylalkylthiosemicarbazides, 2-[2-(benzoylamino)-3-methylbutyrylhydrazono]-3-alkyl-/arylalkyl- 5-non substituted/methyl-1,3-thiazolidinones, were synthesizedand evaluated for their antiviral activity. Antiviral activity of the synthesized compounds werescreened against various types of viruses (Feline Corona Virus (FIPV), Feline Herpes Virus,HSV-1(KOS), HSV-1(TK-KOS ACVr), HSV-2(G), Vaccinia virus, Vesicular stomatitis virus, Varicella-ZosterVirus TK+VZV, Varicella-ZosterVirus TK-VZV, Cytomegalovirus, Respiratory syncytial virus,Coxsackie B4 virus, Parainfluenza-3 virus, Reovirus-1, Sindbis virus and Punta Toro virus) inCRFK, HEL, HeLa and Vero cell cultures. Anti-HIV and cytotoxicity data were also obtainedwith the compounds using the strains HIV-1 (IIIB) and HIV-2 (ROD) in an MT-4/MTT based assay.None of the tested compounds showed antiviral activity at subtoxic concentrations. Forall the synthesized compounds anti-HCV NS5B RdRp activity was not observed at the concentrationof 100 μM which was the highest concentration tested.KEYWORDS: 4-Thiazolidinones, L-valine, anti-HIV activity, anti-HCV activity.
KW  - 4-Thiazolidinones
KW  - L-valine
KW  - anti-HIV activity
KW  - anti-HCV activity
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UR  - https://doi.org/10.12991/mpj.55146
L1  - https://dergipark.org.tr/en/download/article-file/166015
ER  -