TY  - JOUR
T1  - Development of a New and Efficient  Synthesis Method of 1,2,4-Triazole-5- Thione Derivatives
TT  - Development of a New and Efficient  Synthesis Method of 1,2,4-Triazole-5- Thione Derivatives
AU  - Abacı, Güleser
AU  - Rollas, Sevim
AU  - Tatar, Esra
PY  - 2014
DA  - March
DO  - 10.12991/mpj.78866
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 181
EP  - 186
VL  - 17
IS  - 3
LA  - en
AB  - ABSTRACT: 3,4-Disubstituted-2,4-dihydro-5H-1,2,4-triazole-5-thiones were synthesized by a new one-pot, two-step synthesis method which was demonstrated to be superior than the current synthesis methods. The new method involves addition of alkyl/aryl isothiocyanates to substituted hydrazides in ethanol following the refluxing process of intermeadiate in 4N sodium hydroxide solution. According to our new synthesis procedure, reaction has gone to completion within 6 hours by higher product yields and reduced solvent usage. KEYWORDS: 1,2,4-triazole-5-thione, synthesis, method development
KW  - 1
KW  - 2
KW  - 4-triazole-5-thione
KW  - synthesis
KW  - method development
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CR  - Padmaja A, Muralikrishna A, Rajasekhar C, Padmavathi V. Synthesis and antimicrobial activity of pyrrolyl/ pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles. Chem Pharm Bull (Tokyo) 2011; 59: 1509-17.
CR  - Eswaran S, Adhikari AV, Shetty NS. Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety. Eur J Med Chem 2009; 44: 4637-47.
CR  - Gülerman NN, Dogan HN, Rollas S, Johansson C, Celik C. Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities. Farmaco 2001; 56: 953-8.
CR  - Rollas S, Kalyoncuoğlu N, Sür-Altiner D, Yeğenoğlu Y. 5-(4-Aminophenyl)-4-substituted-2,4-dihydro-3H1,2,4-triazole-3-thiones: synthesis and antibacterial and antifungal activities. Pharmazie 1993; 48: 308-9.
CR  - Sharma V, Bhatia R. Triazoles in antifungal theraphy: a review. Int J Res Pharm Biomed 2011; 2: 417-27.
CR  - Kandemirli F, Shvets N, Ünsalan S, Küçükgüzel İ, Rollas S, Kovalishyn V, Dimoglo A. The structure-antituberculosis activity relationships study in a series of 5-(4-aminophenyl)-4-substituted-2,4-dihydro-3H-1,2,4triazole-3-thione derivatives. A combined electronictopological and neural networks approach. Med Chem 2006; 2: 415-22.
CR  - Küçükgüzel İ, Küçükgüzel ŞG, Rollas S, Kiraz M. Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials. Bioorg Med Chem Lett 2001; 11: 1703-7.
UR  - https://doi.org/10.12991/mpj.78866
L1  - https://dergipark.org.tr/en/download/article-file/166036
ER  -