@article{article_188320, title={Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats}, journal={Marmara Pharmaceutical Journal}, volume={18}, pages={66–72}, year={2014}, DOI={10.12991/mpj.2014186122}, author={Özdemir Kumral, Zarife and Şener, Göksel and Yeğen, Berrak}, keywords={Exercise, hypertension, kidney, oxidative stress}, abstract={<p>Epidemiological studies have shown that regular exercise and <br />increased aerobic fitness are associated with a decrease in allcause <br />mortality and morbidity, including diseases related with <br />high blood pressure. However, whether exercise has an antiinflammatory <br />impact on the pathogenesis of hypertension was <br />not elucidated yet. In the present study, to investigate the <br />potential protective and therapeutic effects of exercise training <br />(swimming for 30 min/day, 5 days/week for 9 weeks) on <br />renovascular hypertension (RVH) 10-week-old male Wistar <br />albino rats were divided into 4 groups as sham-operated <br />sedentary control group, sedentary group with RVH (2-Kidney, <br />1-Clip Goldblatt) and two exercised RVH groups, which had <br />9-week training either before the surgery or after the surgery. <br />Systolic blood pressures (SBP) were measured by the tail-cuff <br />method on a weekly basis and at the end of 12 weeks, rats were <br />decapitated to obtain kidneys. SBP were significantly higher in <br />the sedentary RVH group than the control group, whereas in <br />the trained RVH group measurements were not different than <br />those of the control animals. In the renal tissues of the <br />sedentary RVH group, malondialdehyde and myeloperoxidase <br />levels were increased with a concomitant decrease in <br />glutathione levels, while in the trained RVH group the levels <br />were not different than those of the control group. Moreover, <br />in the trained RVH group, superoxide dismutase and catalase <br />levels measured as antioxidant parameters, were also <br />significantly increased as compared with those of the <br />sedentary RVH group. Current results demonstrate that <br />regular moderate training controls high blood pressure in <br />RVH, while RVH-induced oxidative damage in renal tissue is <br />ameliorated through the modulation of oxidant-antioxidant <br />balance. Exercise training does not only improve the <br />circulatory functions, but it also initiates an anti-inflammatory <br />process to defend against the angiotensin-II-induced renal <br />injury. <br />Keywords: Exercise, hypertension, kidney, oxidative stress </p>}, number={2}, publisher={Marmara University}