@article{article_188723, title={Preliminary investigations of antioxidant, antityrosinase, acetylcholinesterase and anti-inflammatory activities of Actinodaphne species}, journal={Marmara Pharmaceutical Journal}, volume={20}, pages={137–143}, year={2016}, DOI={10.12991/mpj.20162048388}, author={Salleh, Wan Mohd Nuzul Hakimi Wan and Ahmad, Farediah}, keywords={Actinodaphne, antioxidant, antityrosinase, acetylcholinesterase, anti-inflammatory}, abstract={<p>The purpose of this study was to investigate the biological activities of extracts from two <em>Actinodaphne </em> species from Malaysia, which are <em>Actinodaphne macrophylla </em> and <em>Actinodaphne pruinosa </em>. The bioactivity studies were determined on their antioxidant, antityrosinase, acetylcholinesterase and anti-inflammatory activities. The methanolic bark extract of <em>A. pruinosa </em> have shown the highest activity on DPPH (IC <sub>50 </sub>: 70.2 μg/mL), ABTS (IC <sub>50 </sub>: 147.2 μg/mL) and phenolic content (55.1 mg gallic acid/g), while the bark extracts of <em>A. macrophylla </em>showed the best inhibitory activity against mushroom tyrosinase (I: 45.2%) and lipoxygenase (I: 69.2%) assays. All extracts have shown strong AChE inhibitory activity (I: 70.5–88.1%), comparable to galantamine (I: 95.9%). The isolation of specific bioactive compounds as well as evaluating their safety may be necessary in the exploration of these species for potential new therapeutic drugs or drug leads. </p>}, number={2}, publisher={Marmara University}