TY  - JOUR
T1  - Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience
AU  - Özdemir, Belma Gözde
AU  - Aydoğdu, Meltem
AU  - Sağlam, Rabia Nur
AU  - Erdemli Kara, İpek Münteha
AU  - Çalık, Duygu
AU  - Çelik, Murat
AU  - Uçar, Mustafa Gazi
AU  - Bilgi, Ahmet
AU  - Çelik, Çetin
PY  - 2026
DA  - March
Y2  - 2026
DO  - 10.47582/jompac.1887249
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 344
EP  - 348
VL  - 7
IS  - 2
LA  - en
AB  - Aims: Sex cord stromal tumors (SCSTs) constitute a rare subgroup of ovarian tumors, exhibiting heterogeneous clinical course and prognosis. The aim of this study is to evaluate clinicopathological factors affecting prognosis in patients with SCSTs based on single-center experience. Methods: This retrospective study included patients diagnosed with SCSTs at Selçuk University between 2010-2025. Demographic characteristics, tumor type, tumor stage, tumor size, mitotic index, surgical approach, adjuvant therapy status, and follow-up duration were recorded. Factors affecting prognosis were analyzed in terms of overall survival and disease-free survival.  Results: A total of 94 patients with ovarian SCSTs were included in the study. Granulosa cell tumors constituted the most common histopathological subtype (n=41, 43.6%), followed by fibroma/thecoma (n=25, 26.6%) and other SCSTs (n=28, 29.8%). The mean age at diagnosis was 58.0±14.6 years. Tumor recurrence was observed in 5 patients (5.3%). At the last follow-up, 79 patients (84.0%) were alive and 15 patients (16.0%) had died. Adjuvant therapy was administered to 6 patients (6.4%), all of whom belonged to the other SCST group. Recurrence and mortality were more frequently observed in granulosa cell tumor and other SCST subgroups.  Conclusion: In SCSTs, stage, mitotic activity, and residual disease after surgery are important factors in determining prognosis. Early diagnosis and optimal cytoreduction positively influence disease-free and overall survival. Larger patient series and multicenter studies with long-term follow-up are needed.
KW  - Sex cord stromal tumors
KW  - ovarian tumors
KW  - prognostic factors
KW  - granulosa cell tumor
KW  - survival
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UR  - https://doi.org/10.47582/jompac.1887249
L1  - https://dergipark.org.tr/en/download/article-file/5709876
ER  -