@article{article_190324, title={The effect of tolmetin on tendon healing (A biomechanical study on rabbits)}, journal={Acta Orthopaedica et Traumatologica Turcica}, volume={33}, pages={216–220}, year={2006}, DOI={10.3944/aott.v33i3.2340}, author={Maralcan, Gokhan and Gokturk, Erol and Turgut, Akin and Kose, Nusret and Seber, Sinan}, abstract={Introduction: The use of NSAIDs are common after musculoskeletal injury or surgeries. The influence of NSAID on tendon healing is controversial. We evaluated the effect of tolmetin on tendon healing. Material and Method: 12 Male New Zealand rabbits randomly selected and tenotomy of the right achilles tendon and cast immobilization in flexion was performed. While 6 rabbits in experimental group receiving 25 mg/kg/day tolmetin via intraperitoneal injection other 6 rabbits consisted the control group and not given tolmetin. All the rabbits were sacrified and achilles tendons were resected at 14 th day. On material testing machine biomechanical evaluation was made. Average tensile force-to-failure was 33.81 newton (N) for the experimental group and 36.95 N for the control group. No statistically significant difference between the groups was found. Discussion: Because the first stage of tendon healing is inflammation, one may expect that while NSAIDs reducing pain and swelling thus providing clinical benefits on the other hand they may interfere with tendon healing. We found that tolmetin has no adverse effect on healing of conservatively treated achilles tendon rupture. Conclusion: During tendon healing tolmetin and probably other similar NSAIDs may be useful since these drugs can reduce adhesions caused by surgery to minimum and increase gliding function of tendon thus an optimum clinical result can be obtained.}, number={3}, publisher={Turkish Association of Orthopaedics and Traumatology}