TY  - JOUR
T1  - Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats
TT  - Sağlıklı sıçanlarda intra-artiküler tenoksikam, diklofenak ve metilprednizolonun kronik etkilerinin karşılaştırılması
AU  - Orak, Mehmet
AU  - Ak, Dursun
AU  - Midi, Ahmet
AU  - Lacin, Berna
AU  - Purisa, Sevim
AU  - Bulut, Guven
PY  - 2015
DA  - August
DO  - 10.3944/AOTT.2015.14.0312
JF  - Acta Orthopaedica et Traumatologica Turcica
PB  - Turkish Association of Orthopaedics and Traumatology
WT  - DergiPark
SN  - 1017-995X
SP  - 438
EP  - 446
VL  - 49
IS  - 4
LA  - en
AB  - Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac. Ten IA injections were administered at 1-week intervals. Rats were sacrificed at 48 h and 1, 2, 4, and 8 weeks after the tenth injection. Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes.Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage.Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment.
KW  - Diclofenac
KW  - experimental study
KW  - intraarticular
KW  - methylprednisolone
KW  - tenoxicam
N2  - Amaç: Dejeneratif eklem hastalığı tedavisinde nonsteroid antiinflamatuar ilaçların (NSAİİ) uzun süreli kullanımından kaynaklanan gastrointestinal yan etkilere karşılık olarak liyofilize NSAİİ üretimi ve intra-artiküler (İA) uygulamaları artmıştır. Diz içine enjekte edilen liyofilize NSAİİ (tenoksikam) ile kortikosteroid (metilprednizolon asetat) ve liyofilize olmayan NSAİİ’nin (diklofenak) tekrarlayan uygulamalarının zararlı etkileri histopatolojik olarak araştırılmıştır.Gereçler ve Yöntemler: Denekler, her biri 25 sıçan içeren dört gruba bölünmüştür; kontrol, metilprednizolon, tenoksikam ve diklofenak. Sıçanların sağ dizlerine bir haftalık aralıklarla toplam 10 doz İA enjeksiyon gerçekleştirilmiştir. Sıçanlar, onuncu enjeksiyondan 48 saat, 1, 2, 4 ve 8 hafta sonra sakrifiye edilmiştir. Histomorfolojik olarak, diz eklemleri osteoartritik değişiklikler bakımından incelenirken mide dokusu da gastritik değişiklikler yönünden incelenmiştir.Bulgular: Diklofenak ve tenoksikam diz ekleminde artmış fibroblast ve fibrozis oluşumuna yol açarken, kortikosteroid artmış fibroblast ve fibrozis oluşumuna yol açmamış; kronik kortikosteroid kullanımı aynı zamanda sinovyum veya kıkırdak doku üzerinde hiçbir negatif etki oluşturmamıştır.Çıkarımlar: Kronik tenoksikam ve diklofenak kullanımı diz ekleminde metilprednizolona kıyasla daha fazla negatif etki oluşturmuştur.DOI: 10.3944/AOTT.2015.14.0312Bu özet, makalenin henüz redaksiyonu tamamlanmamış haline aittir ve bilgi verme amaçlıdır. Yayın aşamasında değişiklik gösterebilir.
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UR  - https://doi.org/10.3944/AOTT.2015.14.0312
L1  - https://dergipark.org.tr/en/download/article-file/170644
L1  - https://dergipark.org.tr/en/download/article-file/170645
ER  -