TY - JOUR T1 - Role of anti-adhesive barriers following rotator cuff repair surgery: an experimental study AU - Kalem, Mahmut AU - Sahin, Ercan AU - Songur, Murat AU - Zehir, Sinan AU - Armangil, Mehmet AU - Demirtaş, Mehmet PY - 2016 DA - March JF - Acta Orthopaedica et Traumatologica Turcica PB - Turkish Association of Orthopaedics and Traumatology WT - DergiPark SN - 1017-995X SP - 227 VL - 50 IS - 2 LA - en AB - Objective: This experimental study investigates the effectiveness of expanded polytetrafluoroethylene (Dualmesh®, Gore Medical, Flagstaff, AZ, USA), sodium hyaluronate-carboxymethyl cellulose (Seprafilm®, Genzyme, Cambridge, MA, USA), and polysiloxane (silicone) as anti-adhesive barriers for inhibition of fibrosis in the subacromial area following rotator cuff repair.Methods: Rabbit rotator cuff tenotomy and repair was conducted on 24 rabbits in 4 groups: control (Group A), Dualmesh® (Group B), Seprafilm® (Group C), and silicone (Group D). Anti-adhesive barrier materials were sutured over the repaired rotator cuff. Macroscopic and histological evaluations were made at the end of the sixth postoperative week.Results: Macroscopic evaluation revealed that minimal adhesion occurred in the control and silicone groups, while the Seprafilm® and Dualmesh® groups showed evidence of fibrosis. Microscopic evaluation revealed diffuse fibrosis and collagen accumulation in the Dualmesh® and Seprafilm® groups, whereas minimal collagen deposition and inflammatory cell reaction was found among the silicone and control groups. Significant differences were found between the silicone and Dualmesh® (p=0.001) and silicone and Seprafilm® groups (p=0.002), as well as between the control and Dualmesh® (p=0.002) and control and Seprafilm® groups (p=0.002).Conclusion: Expanded polytetrafluoroethylene (ePTFE/Dualmesh®) and sodium hyaluronate carboxymethyl cellulose (SH-CMC/Seprafilm®) did not prevent or attenuate postoperative subacromial fibrosis following cuff tear repair. Nor did silicone prevent or attenuate fibrosis. More detailed research is needed for development of an effective anti-adhesive barrier for use after rotator cuff tear surgery. KW - Antiadhesive barrier; rotator cuff; subacromial fibrosis. UR - https://dergipark.org.tr/en/pub/aott/issue//192501 L1 - https://dergipark.org.tr/en/download/article-file/170781 ER -